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DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Michel Thépaut, Joanna Luczkowiak, Corinne Vivès, Nuria Labiod, Isabelle Bally, Fátima Lasala, Yasmina Grimoire, Daphna Fenel, Sara Sattin, Nicole Thielens, Guy Schoehn, Anna Bernardi, Rafael Delgado, Franck Fieschi
doi: https://doi.org/10.1101/2020.08.09.242917
Michel Thépaut
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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Joanna Luczkowiak
2Instituto de Investigación Hospital Universitario 12 de Octubre (imas12), Universidad Complutense School of Medicine, 28041 Madrid, Spain
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Corinne Vivès
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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Nuria Labiod
2Instituto de Investigación Hospital Universitario 12 de Octubre (imas12), Universidad Complutense School of Medicine, 28041 Madrid, Spain
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Isabelle Bally
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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Fátima Lasala
2Instituto de Investigación Hospital Universitario 12 de Octubre (imas12), Universidad Complutense School of Medicine, 28041 Madrid, Spain
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Yasmina Grimoire
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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Daphna Fenel
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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Sara Sattin
3Universita’ degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy
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Nicole Thielens
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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Guy Schoehn
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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Anna Bernardi
3Universita’ degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy
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Rafael Delgado
2Instituto de Investigación Hospital Universitario 12 de Octubre (imas12), Universidad Complutense School of Medicine, 28041 Madrid, Spain
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  • For correspondence: rafael.delgado@salud.madrid.org franck.fieschi@ibs.fr
Franck Fieschi
1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
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  • For correspondence: rafael.delgado@salud.madrid.org franck.fieschi@ibs.fr
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Article Information

doi 
https://doi.org/10.1101/2020.08.09.242917
History 
  • August 10, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Michel Thépaut1,4,
  2. Joanna Luczkowiak2,4,
  3. Corinne Vivès1,
  4. Nuria Labiod2,
  5. Isabelle Bally1,
  6. Fátima Lasala2,
  7. Yasmina Grimoire1,
  8. Daphna Fenel1,
  9. Sara Sattin3,
  10. Nicole Thielens1,
  11. Guy Schoehn1,
  12. Anna Bernardi3,
  13. Rafael Delgado2,* and
  14. Franck Fieschi1,*
  1. 1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France
  2. 2Instituto de Investigación Hospital Universitario 12 de Octubre (imas12), Universidad Complutense School of Medicine, 28041 Madrid, Spain
  3. 3Universita’ degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy
  1. ↵*Correspondance: rafael.delgado{at}salud.madrid.org, franck.fieschi{at}ibs.fr
  1. ↵4 These authors contributed equally

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DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist
Michel Thépaut, Joanna Luczkowiak, Corinne Vivès, Nuria Labiod, Isabelle Bally, Fátima Lasala, Yasmina Grimoire, Daphna Fenel, Sara Sattin, Nicole Thielens, Guy Schoehn, Anna Bernardi, Rafael Delgado, Franck Fieschi
bioRxiv 2020.08.09.242917; doi: https://doi.org/10.1101/2020.08.09.242917
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DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist
Michel Thépaut, Joanna Luczkowiak, Corinne Vivès, Nuria Labiod, Isabelle Bally, Fátima Lasala, Yasmina Grimoire, Daphna Fenel, Sara Sattin, Nicole Thielens, Guy Schoehn, Anna Bernardi, Rafael Delgado, Franck Fieschi
bioRxiv 2020.08.09.242917; doi: https://doi.org/10.1101/2020.08.09.242917

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