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Bmp8a Is a Novel Player in Regulation of Antiviral Immunity

View ORCID ProfileShenjie Zhong, Haoyi Li, Yun-Sheng Wang, Ying Wang, Guangdong Ji, Hong-Yan Li, Shicui Zhang, Zhenhui Liu
doi: https://doi.org/10.1101/2020.08.09.243519
Shenjie Zhong
College of Marine Life Science and Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
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  • ORCID record for Shenjie Zhong
Haoyi Li
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Yun-Sheng Wang
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Ying Wang
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Guangdong Ji
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Hong-Yan Li
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Shicui Zhang
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  • For correspondence: sczhang@ouc.edu.cn
Zhenhui Liu
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  • For correspondence: zhenhuiliu@ouc.edu.cn
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Abstract

Bone morphogenetic protein (BMP) is a kind of classical multi-functional growth factor that plays a vital role in the formation and maintenance of bone, cartilage, muscle, blood vessels, and the regulation of energy balance. Whether BMP plays a role in antiviral immunity is unknown. Here we demonstrate that Bmp8a is a newly-identified positive regulator for antiviral immune responses. The bmp8a−/− zebrafish, when infected with the viruses of GCRV, SVCV or TSVDV, show significantly reduced antiviral immunity, increased viral load and morbidity. We also show for the first time that Bmp8a interacts with Alk6a, which promotes the phosphorylation of Tbk1 and Irf3 through p38 MAPK pathway, and induces the production of type I IFNs in response to virus infection. Upon virus infection, bmp8a expression is activated through the binding of Stat1a/Stat1b to the GAS motifs in bmp8a promoter region, enlarging the antiviral innate immune signal. Our study uncovers a previously unrecognized role of Bmp8a in regulation of antiviral immune responses and provides a new target for controlling viral infection.

Competing Interest Statement

The work is under a patent in China: A method to improve the antiviral immunity of fish (Application No.201910454499.6).

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted September 10, 2020.
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Bmp8a Is a Novel Player in Regulation of Antiviral Immunity
Shenjie Zhong, Haoyi Li, Yun-Sheng Wang, Ying Wang, Guangdong Ji, Hong-Yan Li, Shicui Zhang, Zhenhui Liu
bioRxiv 2020.08.09.243519; doi: https://doi.org/10.1101/2020.08.09.243519
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Bmp8a Is a Novel Player in Regulation of Antiviral Immunity
Shenjie Zhong, Haoyi Li, Yun-Sheng Wang, Ying Wang, Guangdong Ji, Hong-Yan Li, Shicui Zhang, Zhenhui Liu
bioRxiv 2020.08.09.243519; doi: https://doi.org/10.1101/2020.08.09.243519

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