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Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients: in vitro and in vivo preliminary evidences

Elena Campione, Caterina Lanna, Terenzio Cosio, Luigi Rosa, Maria Pia Conte, Federico Iacovelli, Alice Romeo, Mattia Falconi, Claudia Del Vecchio, Elisa Franchin, Maria Stella Lia, Marilena Minieri, Carlo Chiaramonte, Marco Ciotti, Marzia Nuccetelli, Alessandro Terrinoni, Andrea Magrini, Sergio Bernardini, Massimo Andreoni, Loredana Sarmati, Alessandro Miani, Prisco Piscitelli, Piera Valenti, Luca Bianchi
doi: https://doi.org/10.1101/2020.08.11.244996
Elena Campione
1Dermatology Unit, Tor Vergata University Hospital, Department of Systems Medicine, Rome, 00133, Italy
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  • For correspondence: elena.campione@uniroma2.it campioneelena@hotmail.com
Caterina Lanna
1Dermatology Unit, Tor Vergata University Hospital, Department of Systems Medicine, Rome, 00133, Italy
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Terenzio Cosio
1Dermatology Unit, Tor Vergata University Hospital, Department of Systems Medicine, Rome, 00133, Italy
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Luigi Rosa
2Department of Public Health and Infectious Diseases, University of Rome “La Sapienza”, 00185, Italy
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Maria Pia Conte
2Department of Public Health and Infectious Diseases, University of Rome “La Sapienza”, 00185, Italy
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Federico Iacovelli
3Department of Biology, Structural Bioinformatics Group, University of Rome “Tor Vergata”, Rome, 00133, Italy
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Alice Romeo
3Department of Biology, Structural Bioinformatics Group, University of Rome “Tor Vergata”, Rome, 00133, Italy
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Mattia Falconi
3Department of Biology, Structural Bioinformatics Group, University of Rome “Tor Vergata”, Rome, 00133, Italy
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Claudia Del Vecchio
4Department of Molecular Medicine, University of Padova, 35122 Padova, Italy
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Elisa Franchin
4Department of Molecular Medicine, University of Padova, 35122 Padova, Italy
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Maria Stella Lia
5Department of Experimental Medicine, Tor Vergata University Hospital, Rome, 00133, Italy
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Marilena Minieri
5Department of Experimental Medicine, Tor Vergata University Hospital, Rome, 00133, Italy
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Carlo Chiaramonte
6Department of statistics, University of Rome Tor Vergata, Rome, 00133, Italy
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Marco Ciotti
7Virology Unit, Tor Vergata University Hospital, Rome, 00133, Italy
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Marzia Nuccetelli
8Laboratory Medicine, Department of Experimental Medicine and Surgery, Tor Vergata University Hospital
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Alessandro Terrinoni
5Department of Experimental Medicine, Tor Vergata University Hospital, Rome, 00133, Italy
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Andrea Magrini
9Occupational Medicine Department, University of Rome “Tor Vergata”, Rome, 00133, Italy
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Sergio Bernardini
8Laboratory Medicine, Department of Experimental Medicine and Surgery, Tor Vergata University Hospital
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Massimo Andreoni
13Infectious Disease Unit, Tor Vergata University Hospital, Rome, 00133, Italy
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Loredana Sarmati
13Infectious Disease Unit, Tor Vergata University Hospital, Rome, 00133, Italy
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Alessandro Miani
14Department of Environmental Sciences and Policy, University of Milan, Via Celoria 2, 20133 Milan, Italy
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Prisco Piscitelli
15UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico II, 80131 Naples, Italy
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Piera Valenti
2Department of Public Health and Infectious Diseases, University of Rome “La Sapienza”, 00185, Italy
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Luca Bianchi
1Dermatology Unit, Tor Vergata University Hospital, Department of Systems Medicine, Rome, 00133, Italy
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Article Information

doi 
https://doi.org/10.1101/2020.08.11.244996
History 
  • December 22, 2020.

Article Versions

  • Version 1 (August 11, 2020 - 16:13).
  • Version 2 (August 14, 2020 - 14:40).
  • Version 3 (August 17, 2020 - 23:10).
  • You are viewing Version 4, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Elena Campione1,*,
  2. Caterina Lanna1,
  3. Terenzio Cosio1,
  4. Luigi Rosa2,
  5. Maria Pia Conte2,
  6. Federico Iacovelli3,
  7. Alice Romeo3,
  8. Mattia Falconi3,
  9. Claudia Del Vecchio4,
  10. Elisa Franchin4,
  11. Maria Stella Lia5,
  12. Marilena Minieri5,
  13. Carlo Chiaramonte6,
  14. Marco Ciotti7,
  15. Marzia Nuccetelli8,
  16. Alessandro Terrinoni5,
  17. Andrea Magrini9,
  18. Sergio Bernardini8,
  19. Massimo Andreoni13,
  20. Loredana Sarmati13,
  21. Alessandro Miani14,
  22. Prisco Piscitelli15,
  23. Piera Valenti2,§ and
  24. Luca Bianchi1,§
  1. ↵*Correspondence:
    elena.campione{at}uniroma2.it; campioneelena{at}hotmail.com
    1. 1Dermatology Unit, Tor Vergata University Hospital, Department of Systems Medicine, Rome, 00133, Italy
    2. 2Department of Public Health and Infectious Diseases, University of Rome “La Sapienza”, 00185, Italy
    3. 3Department of Biology, Structural Bioinformatics Group, University of Rome “Tor Vergata”, Rome, 00133, Italy
    4. 4Department of Molecular Medicine, University of Padova, 35122 Padova, Italy
    5. 5Department of Experimental Medicine, Tor Vergata University Hospital, Rome, 00133, Italy
    6. 6Department of statistics, University of Rome Tor Vergata, Rome, 00133, Italy
    7. 7Virology Unit, Tor Vergata University Hospital, Rome, 00133, Italy
    8. 8Laboratory Medicine, Department of Experimental Medicine and Surgery, Tor Vergata University Hospital
    9. 9Occupational Medicine Department, University of Rome “Tor Vergata”, Rome, 00133, Italy
    10. 10Villa dei Pini Hospital, Anzio (RM), Italy
    11. 11Pineta Grande Hospital, Caserta, Italy
    12. 12Fimmg provincial, Rome, Italy
    13. 13Infectious Disease Unit, Tor Vergata University Hospital, Rome, 00133, Italy
    14. 14Department of Environmental Sciences and Policy, University of Milan, Via Celoria 2, 20133 Milan, Italy
    15. 15UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico II, 80131 Naples, Italy
    1. ↵§ Those authors equally contributed as senior authors

    2. Author Contributions: Conceptualization, EC, PV, LB, MF, AM; Formal analysis, CC; Investigation, EC, TC, LR, MPC, FI, AR, CDV,EF, SL,MM, MC, MN, AT, II, LC, AM, SB, NM, SS, FR, PLB; Writing- original draft, CL, EC, LR, LB, PV, MF; Writing-review & editing, EC, LB, PV

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    Posted December 22, 2020.
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    Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients: in vitro and in vivo preliminary evidences
    Elena Campione, Caterina Lanna, Terenzio Cosio, Luigi Rosa, Maria Pia Conte, Federico Iacovelli, Alice Romeo, Mattia Falconi, Claudia Del Vecchio, Elisa Franchin, Maria Stella Lia, Marilena Minieri, Carlo Chiaramonte, Marco Ciotti, Marzia Nuccetelli, Alessandro Terrinoni, Andrea Magrini, Sergio Bernardini, Massimo Andreoni, Loredana Sarmati, Alessandro Miani, Prisco Piscitelli, Piera Valenti, Luca Bianchi
    bioRxiv 2020.08.11.244996; doi: https://doi.org/10.1101/2020.08.11.244996
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    Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients: in vitro and in vivo preliminary evidences
    Elena Campione, Caterina Lanna, Terenzio Cosio, Luigi Rosa, Maria Pia Conte, Federico Iacovelli, Alice Romeo, Mattia Falconi, Claudia Del Vecchio, Elisa Franchin, Maria Stella Lia, Marilena Minieri, Carlo Chiaramonte, Marco Ciotti, Marzia Nuccetelli, Alessandro Terrinoni, Andrea Magrini, Sergio Bernardini, Massimo Andreoni, Loredana Sarmati, Alessandro Miani, Prisco Piscitelli, Piera Valenti, Luca Bianchi
    bioRxiv 2020.08.11.244996; doi: https://doi.org/10.1101/2020.08.11.244996

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