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Whole genome CRISPR screens identify LRRK2-regulated endocytosis as a major mechanism for extracellular tau uptake by human neurons
Lewis D. Evans, Alessio Strano, Ashley Campbell, Emre Karakoc, View ORCID ProfileFrancesco Iorio, Andrew R. Bassett, View ORCID ProfileFrederick J. Livesey
doi: https://doi.org/10.1101/2020.08.11.246363
Lewis D. Evans
1UCL Great Ormond Street Institute of Child Health, Department of Developmental Biology and Cancer, Zayed Centre for Research into Rare Disease in Children, 20 Guilford Street, London WC1N 1DZ, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Alessio Strano
1UCL Great Ormond Street Institute of Child Health, Department of Developmental Biology and Cancer, Zayed Centre for Research into Rare Disease in Children, 20 Guilford Street, London WC1N 1DZ, UK
Ashley Campbell
1UCL Great Ormond Street Institute of Child Health, Department of Developmental Biology and Cancer, Zayed Centre for Research into Rare Disease in Children, 20 Guilford Street, London WC1N 1DZ, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Emre Karakoc
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
3Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Francesco Iorio
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
3Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Andrew R. Bassett
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
3Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Frederick J. Livesey
1UCL Great Ormond Street Institute of Child Health, Department of Developmental Biology and Cancer, Zayed Centre for Research into Rare Disease in Children, 20 Guilford Street, London WC1N 1DZ, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Article usage
Posted August 11, 2020.
Whole genome CRISPR screens identify LRRK2-regulated endocytosis as a major mechanism for extracellular tau uptake by human neurons
Lewis D. Evans, Alessio Strano, Ashley Campbell, Emre Karakoc, Francesco Iorio, Andrew R. Bassett, Frederick J. Livesey
bioRxiv 2020.08.11.246363; doi: https://doi.org/10.1101/2020.08.11.246363
Whole genome CRISPR screens identify LRRK2-regulated endocytosis as a major mechanism for extracellular tau uptake by human neurons
Lewis D. Evans, Alessio Strano, Ashley Campbell, Emre Karakoc, Francesco Iorio, Andrew R. Bassett, Frederick J. Livesey
bioRxiv 2020.08.11.246363; doi: https://doi.org/10.1101/2020.08.11.246363
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