Abstract
Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity to the human coronaviruses (HCoV) SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report the identification of humoral immune responses to SARS-CoV-2 and other HCoV peptides that can be used to detect asymptomatic, mild and, severe SARS-CoV-2 infections, and may enable the discovery of biomarkers for immunity following infection or vaccination.
Competing Interest Statement
NM, SJ, CG, RaT, TB, and WIL are listed as the inventors on a patent filed that is related to findings in this study. Application: 63/005,865 Title: Peptide Sequences for Detection and Differentiation of Antibody Responses to SARS-CoV-2 and Other Human Corona Viruses Application Type PRO - Provisional Status: Filed Country: United States IRs: CU20309 IR Received: 2020-04-02 Filing Date: 2020-04-06 Inventor(s) : Nischay Mishra; W. Ian Lipkin M.D.; Rafal Tokarz; Shreyas Joshi; Cheng Guo; Thomas Briese;
