New Results
Differential GLP-1R binding and activation by peptide and non-peptide agonists
Xin Zhang, Matthew J. Belousoff, Peishen Zhao, Albert J. Kooistra, Tin T. Truong, Sheng Yu Ang, Christina Rye Underwood, Thomas Egebjerg, Petr Šenel, Gregory D. Stewart, Yi-Lynn Liang, Alisa Glukhova, Hari Venugopal, Arthur Christopoulos, Sebastian G. B. Furness, Laurence J. Miller, Steffen Reedtz-Runge, View ORCID ProfileChristopher J. Langmead, David E. Gloriam, View ORCID ProfileRadostin Danev, View ORCID ProfilePatrick M. Sexton, Denise Wootten
doi: https://doi.org/10.1101/2020.08.16.252585
Xin Zhang
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Matthew J. Belousoff
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Peishen Zhao
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Albert J. Kooistra
2Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
Tin T. Truong
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Sheng Yu Ang
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Christina Rye Underwood
3Novo Nordisk A/S, Novo Nordisk Park, Copenhagen, Denmark
Thomas Egebjerg
3Novo Nordisk A/S, Novo Nordisk Park, Copenhagen, Denmark
Petr Šenel
4Apigenex, Poděbradská 173/5, Prague 9, 190 00 Czech Republic
Gregory D. Stewart
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Yi-Lynn Liang
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Alisa Glukhova
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Hari Venugopal
5Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Victoria, 3168, Australia.
Arthur Christopoulos
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Sebastian G. B. Furness
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Laurence J. Miller
6Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, U.S.A.
Steffen Reedtz-Runge
3Novo Nordisk A/S, Novo Nordisk Park, Copenhagen, Denmark
Christopher J. Langmead
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
David E. Gloriam
2Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
Radostin Danev
7Graduate School of Medicine, University of Tokyo, N415, 7-3-1 Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan
Patrick M. Sexton
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Denise Wootten
1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
Posted August 16, 2020.
Differential GLP-1R binding and activation by peptide and non-peptide agonists
Xin Zhang, Matthew J. Belousoff, Peishen Zhao, Albert J. Kooistra, Tin T. Truong, Sheng Yu Ang, Christina Rye Underwood, Thomas Egebjerg, Petr Šenel, Gregory D. Stewart, Yi-Lynn Liang, Alisa Glukhova, Hari Venugopal, Arthur Christopoulos, Sebastian G. B. Furness, Laurence J. Miller, Steffen Reedtz-Runge, Christopher J. Langmead, David E. Gloriam, Radostin Danev, Patrick M. Sexton, Denise Wootten
bioRxiv 2020.08.16.252585; doi: https://doi.org/10.1101/2020.08.16.252585
Differential GLP-1R binding and activation by peptide and non-peptide agonists
Xin Zhang, Matthew J. Belousoff, Peishen Zhao, Albert J. Kooistra, Tin T. Truong, Sheng Yu Ang, Christina Rye Underwood, Thomas Egebjerg, Petr Šenel, Gregory D. Stewart, Yi-Lynn Liang, Alisa Glukhova, Hari Venugopal, Arthur Christopoulos, Sebastian G. B. Furness, Laurence J. Miller, Steffen Reedtz-Runge, Christopher J. Langmead, David E. Gloriam, Radostin Danev, Patrick M. Sexton, Denise Wootten
bioRxiv 2020.08.16.252585; doi: https://doi.org/10.1101/2020.08.16.252585
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