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Effects of Peripheral Haptic Feedback on Intracortical Brain-Computer Interface Control and Associated Sensory Responses in Motor Cortex

View ORCID ProfileDarrel R. Deo, View ORCID ProfilePaymon Rezaii, View ORCID ProfileLeigh R. Hochberg, View ORCID ProfileAllison M. Okamura, View ORCID ProfileKrishna V. Shenoy, View ORCID ProfileJaimie M. Henderson
doi: https://doi.org/10.1101/2020.08.17.240648
Darrel R. Deo
1Departments of Mechanical Engineering and Neurosurgery, Stanford University, Stanford, CA
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  • For correspondence: ddeo@stanford.edu
Paymon Rezaii
2Department of Neurosurgery, Stanford University, Stanford, CA
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Leigh R. Hochberg
3VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Providence VA Medical Center, Providence, RI; School of Engineering and Carney Institute for Brain Science, Brown University, Providence, RI; Department of Neurology, Harvard Medical School, Boston, MA; and Center for Neurotechnology and Neurorecovery, Dept. of Neurology, Massachusetts General Hospital, Boston, MA
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Allison M. Okamura
4Department of Mechanical Engineering and Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA
Roles: Fellow, IEEE
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Krishna V. Shenoy
5Departments of Electrical Engineering, Bioengineering and Neurobiology, Howard Hughes Medical Institute, Wu Tsai Neurosciences Institute, and Bio-X Institute at Stanford University, Stanford, CA
Roles: Senior Member, IEEE
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Jaimie M. Henderson
6Department of Neurosurgery, Wu Tsai Neurosciences Institute, and Bio-X Institute at Stanford University, Stanford, CA
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Abstract

Intracortical brain-computer interfaces (iBCIs) provide people with paralysis a means to control devices with signals decoded from brain activity. Despite recent impressive advances, these devices still cannot approach able-bodied levels of control. To achieve naturalistic control and improved performance of neural prostheses, iBCIs will likely need to include proprioceptive feedback. With the goal of providing proprioceptive feedback via mechanical haptic stimulation, we aim to understand how haptic stimulation affects motor cortical neurons and ultimately, iBCI control. We provided skin shear haptic stimulation as a substitute for proprioception to the back of the neck of a person with tetraplegia. The neck location was determined via assessment of touch sensitivity using a monofilament test kit. The participant was able to correctly report skin shear at the back of the neck in 8 unique directions with 65% accuracy. We found motor cortical units that exhibited sensory responses to shear stimuli, some of which were strongly tuned to the stimuli and well modeled by cosine-shaped functions. We also demonstrated online iBCI cursor control with continuous skin-shear feedback driven by decoded command signals. Cursor control performance increased slightly but significantly when the participant was given haptic feedback, compared to the purely visual feedback condition.

Competing Interest Statement

The MGH Translational Research Center has a clinical research support agreement with Neuralink, Paradromics, and Synchron, for which LRH provides consultative input. AMO is a consultant for Hyundai CRADLE. JMH is a consultant for Neuralink Corp. and Proteus Biomedical, and serves on the Medical Advisory Board of Enspire DBS. KVS consults for Neuralink Corp. and CTRL-Labs Inc. (part of Facebook Reality Labs) and is on the scientific advisory boards of MIND-X Inc., Inscopix Inc., and Heal Inc. All other authors have no competing interests.

Footnotes

  • E-mail: ddeo{at}stanford.edu, E-mail: prezaii{at}stanford.edu, E-mail: leigh_hochberg{at}brown.edu, E-mail: aokamura{at}stanford.edu, E-mail: shenoy{at}stanford.edu, E-mail: henderj{at}stanford.edu

  • ↵† Co-senior authors

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 08, 2021.
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Effects of Peripheral Haptic Feedback on Intracortical Brain-Computer Interface Control and Associated Sensory Responses in Motor Cortex
Darrel R. Deo, Paymon Rezaii, Leigh R. Hochberg, Allison M. Okamura, Krishna V. Shenoy, Jaimie M. Henderson
bioRxiv 2020.08.17.240648; doi: https://doi.org/10.1101/2020.08.17.240648
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Effects of Peripheral Haptic Feedback on Intracortical Brain-Computer Interface Control and Associated Sensory Responses in Motor Cortex
Darrel R. Deo, Paymon Rezaii, Leigh R. Hochberg, Allison M. Okamura, Krishna V. Shenoy, Jaimie M. Henderson
bioRxiv 2020.08.17.240648; doi: https://doi.org/10.1101/2020.08.17.240648

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