Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention

Satoshi Watanabe, Tohru Kurotani, Tomofumi Oga, Jun Noguchi, Risa Isoda, Akiko Nakagami, Kazuhisa Sakai, Keiko Nakagaki, Kayo Sumida, Kohei Hoshino, Koichi Saito, Izuru Miyawaki, Masayuki Sekiguchi, Keiji Wada, Takafumi Minamimoto, Noritaka Ichinohe
doi: https://doi.org/10.1101/2020.08.18.255240
Satoshi Watanabe
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: nichino@ncnp.go.jp s-watanabe@ncnp.go.jp
Tohru Kurotani
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomofumi Oga
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jun Noguchi
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Risa Isoda
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akiko Nakagami
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
2Department of Psychology, Japan Women’s University, Kanagawa, 214-8565, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazuhisa Sakai
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Keiko Nakagaki
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kayo Sumida
3Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Osaka, 554-8558, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kohei Hoshino
4Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd., Osaka, 554-0022, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Koichi Saito
3Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Osaka, 554-8558, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Izuru Miyawaki
4Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd., Osaka, 554-0022, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masayuki Sekiguchi
5Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Keiji Wada
5Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takafumi Minamimoto
6Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, 263-8555, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Noritaka Ichinohe
1Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: nichino@ncnp.go.jp s-watanabe@ncnp.go.jp
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Autism spectrum disorder (ASD) is a synapse-related disorder that is diagnosed at around 3 years of age. Earlier intervention is desirable for better ASD prognosis; however, there is limited biological literature regarding early-age ASD. This study aimed to assess altered cortical synapses and gene expression in the ASD model marmoset. There were distinct phenotypes in the model animals across the neonate, childhood, and mature stages in the dorsomedial prefrontal cortex (Brodmann area 8b/9). At the neonate stage, synapses were underdeveloped and modulated genes were enriched with synaptogenesis- and ASD-related genes. At the childhood stage, synaptic features and gene expressions associated with experience-dependent circuit remodeling were altered in model animals. At the mature stage, there were synapse overdevelopment and altered gene expression similar to those in human ASD. These early synaptic phenotypes and altered gene expressions could be novel targets of efficient therapy from a young age.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted August 18, 2020.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention
Satoshi Watanabe, Tohru Kurotani, Tomofumi Oga, Jun Noguchi, Risa Isoda, Akiko Nakagami, Kazuhisa Sakai, Keiko Nakagaki, Kayo Sumida, Kohei Hoshino, Koichi Saito, Izuru Miyawaki, Masayuki Sekiguchi, Keiji Wada, Takafumi Minamimoto, Noritaka Ichinohe
bioRxiv 2020.08.18.255240; doi: https://doi.org/10.1101/2020.08.18.255240
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention
Satoshi Watanabe, Tohru Kurotani, Tomofumi Oga, Jun Noguchi, Risa Isoda, Akiko Nakagami, Kazuhisa Sakai, Keiko Nakagaki, Kayo Sumida, Kohei Hoshino, Koichi Saito, Izuru Miyawaki, Masayuki Sekiguchi, Keiji Wada, Takafumi Minamimoto, Noritaka Ichinohe
bioRxiv 2020.08.18.255240; doi: https://doi.org/10.1101/2020.08.18.255240

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (2638)
  • Biochemistry (5231)
  • Bioengineering (3653)
  • Bioinformatics (15746)
  • Biophysics (7225)
  • Cancer Biology (5604)
  • Cell Biology (8060)
  • Clinical Trials (138)
  • Developmental Biology (4745)
  • Ecology (7475)
  • Epidemiology (2059)
  • Evolutionary Biology (10535)
  • Genetics (7707)
  • Genomics (10091)
  • Immunology (5168)
  • Microbiology (13844)
  • Molecular Biology (5361)
  • Neuroscience (30625)
  • Paleontology (213)
  • Pathology (873)
  • Pharmacology and Toxicology (1520)
  • Physiology (2236)
  • Plant Biology (4991)
  • Scientific Communication and Education (1039)
  • Synthetic Biology (1382)
  • Systems Biology (4135)
  • Zoology (808)