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SuperStructure: a Parameter-Free Super-Structure Identifier for SMLM Data

View ORCID ProfileM. Marenda, E. Lazarova, S. van de Linde, View ORCID ProfileN. Gilbert, View ORCID ProfileD. Michieletto
doi: https://doi.org/10.1101/2020.08.19.254540
M. Marenda
1SUPA, School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Road, Edinburgh, EH9 3FD, UK
2MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
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E. Lazarova
2MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
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S. van de Linde
3SUPA, Department of Physics, University of Strathclyde, Glasgow G4 0NG, UK
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N. Gilbert
2MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
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D. Michieletto
1SUPA, School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Road, Edinburgh, EH9 3FD, UK
2MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
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Abstract

Single-Molecule Localisation Microscopy (SMLM) allows the quantitative mapping of molecules at high resolution. However, understanding the non-random interaction of proteins requires the identification of more complex patterns than those typified by standard clustering tools. Here we introduce SuperStructure, a parameter-free algorithm to quantify structures made of inter-connected clusters, such as protein gels. SuperStructure works without a priori assumptions and is thus an ideal methodology for standardised analysis of SMLM data.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://git.ecdf.ed.ac.uk/dmichiel/superstructure/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 20, 2020.
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SuperStructure: a Parameter-Free Super-Structure Identifier for SMLM Data
M. Marenda, E. Lazarova, S. van de Linde, N. Gilbert, D. Michieletto
bioRxiv 2020.08.19.254540; doi: https://doi.org/10.1101/2020.08.19.254540
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SuperStructure: a Parameter-Free Super-Structure Identifier for SMLM Data
M. Marenda, E. Lazarova, S. van de Linde, N. Gilbert, D. Michieletto
bioRxiv 2020.08.19.254540; doi: https://doi.org/10.1101/2020.08.19.254540

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