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Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressed Drosophila

View ORCID ProfileAtulya Srisudarshan Ram Iyengar, Hongyu Ruan, View ORCID ProfileChun-Fang Wu
doi: https://doi.org/10.1101/2020.08.19.257832
Atulya Srisudarshan Ram Iyengar
1Department of Biology, University of Iowa, Iowa City, IA 52242 USA
2Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USA
3Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242 USA
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Hongyu Ruan
1Department of Biology, University of Iowa, Iowa City, IA 52242 USA
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Chun-Fang Wu
1Department of Biology, University of Iowa, Iowa City, IA 52242 USA
2Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USA
3Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242 USA
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  • For correspondence: chun-fang-wu@uiowa.edu
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Abstract

We examined several sensory-motor processing circuits in Drosophila across the lifespan and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. We observed relatively little deterioration toward the end of lifespan in the giant-fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex. In contrast, we found substantial age-dependent modifications in the performance of GF inputs and other circuits driving flight motoneuron activities. Importantly, in high temperature (HT)-reared flies (29 °C), the characteristic age-dependent progression of these properties was largely maintained, albeit over a compressed time scale, lending support for the common practice of expediting Drosophila aging studies by HT rearing. We discovered shortened lifespans in Cu2+/Zn2+ Superoxide Dismutase 1 (Sod) mutant flies were accompanied by alterations distinct from HT-reared flies, highlighting differential effects of oxidative vs temperature stressors. This work also establishes several age-vulnerable parameters that may serve as quantitative neurophysiological landmarks for aging in Drosophila.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 08, 2020.
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Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressed Drosophila
Atulya Srisudarshan Ram Iyengar, Hongyu Ruan, Chun-Fang Wu
bioRxiv 2020.08.19.257832; doi: https://doi.org/10.1101/2020.08.19.257832
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Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressed Drosophila
Atulya Srisudarshan Ram Iyengar, Hongyu Ruan, Chun-Fang Wu
bioRxiv 2020.08.19.257832; doi: https://doi.org/10.1101/2020.08.19.257832

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