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Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

View ORCID ProfileMelissa J Polonenko, View ORCID ProfileRoss K Maddox
doi: https://doi.org/10.1101/2020.08.20.258301
Melissa J Polonenko
Department of Biomedical Engineering, Department of Neuroscience, Del Monte Institute for Neuroscience, Center for Visual Science, University of Rochester
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Ross K Maddox
Department of Biomedical Engineering, Department of Neuroscience, Del Monte Institute for Neuroscience, Center for Visual Science, University of Rochester
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  • For correspondence: ross.maddox@rochester.edu
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ABSTRACT

The auditory brainstem is important for processing speech, yet we have much to learn regarding the contributions of different subcortical structures. These deep neural generators respond quickly, making them difficult to study during dynamic, ongoing speech. Recently developed techniques have paved the way to use natural speech stimuli, but the auditory brainstem responses (ABRs) they provide are temporally broad and thus have ambiguous neural sources. Here we describe a new method that uses re-synthesized “peaky” speech stimuli and deconvolution analysis of EEG data to measure canonical ABRs to continuous naturalistic speech of male and female narrators. We show that in adults with normal hearing, peaky speech quickly yields robust ABRs that can be used to investigate speech processing at distinct subcortical structures from auditory nerve to rostral brainstem. We further demonstrate the versatility of peaky speech by simultaneously measuring bilateral and ear-specific responses across different frequency bands. Thus, the peaky speech method holds promise as a powerful tool for investigating speech processing and for clinical applications.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted August 20, 2020.
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Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech
Melissa J Polonenko, Ross K Maddox
bioRxiv 2020.08.20.258301; doi: https://doi.org/10.1101/2020.08.20.258301
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Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech
Melissa J Polonenko, Ross K Maddox
bioRxiv 2020.08.20.258301; doi: https://doi.org/10.1101/2020.08.20.258301

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