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Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva

View ORCID ProfileCsaba Verasztó, Sanja Jasek, Martin Gühmann, Réza Shahidi, Nobuo Ueda, James David Beard, Sara Mendes, Konrad Heinz, Luis Alberto Bezares-Calderón, Elizabeth Williams, View ORCID ProfileGáspár Jékely
doi: https://doi.org/10.1101/2020.08.21.260984
Csaba Verasztó
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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  • ORCID record for Csaba Verasztó
Sanja Jasek
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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Martin Gühmann
2Max Planck Institute for Developmental Biology, Tübingen, Germany
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Réza Shahidi
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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Nobuo Ueda
2Max Planck Institute for Developmental Biology, Tübingen, Germany
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James David Beard
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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Sara Mendes
2Max Planck Institute for Developmental Biology, Tübingen, Germany
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Konrad Heinz
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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Luis Alberto Bezares-Calderón
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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Elizabeth Williams
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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Gáspár Jékely
1Living Systems Institute, University of Exeter, Stocker Road, Exeter, UK
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  • ORCID record for Gáspár Jékely
  • For correspondence: g.jekely@exeter.ac.uk
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Abstract

Nervous systems coordinate effectors across the body during movements. We know little about the cellular-level structure of synaptic circuits for such body-wide control. Here we describe the whole-body synaptic connectome and cell-type complement of a three-segmented larva of the marine annelid Platynereis dumerilii. We reconstructed and annotated over 1,500 neurons and 6,500 non-neuronal cells in a whole-body serial electron microscopy dataset. The differentiated cells fall into 180 neuronal and 90 non-neuronal cell types. We analyse the modular network architecture of the entire nervous system and describe polysynaptic pathways from 428 sensory neurons to four effector systems – ciliated cells, glands, pigment cells and muscles. The complete somatic musculature and its innervation will be described in a companion paper. We also investigated intersegmental differences in cell-type complement, descending and ascending pathways, and mechanosensory and peptidergic circuits. Our work provides the basis for understanding whole-body coordination in annelids.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted August 22, 2020.
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Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva
Csaba Verasztó, Sanja Jasek, Martin Gühmann, Réza Shahidi, Nobuo Ueda, James David Beard, Sara Mendes, Konrad Heinz, Luis Alberto Bezares-Calderón, Elizabeth Williams, Gáspár Jékely
bioRxiv 2020.08.21.260984; doi: https://doi.org/10.1101/2020.08.21.260984
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Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva
Csaba Verasztó, Sanja Jasek, Martin Gühmann, Réza Shahidi, Nobuo Ueda, James David Beard, Sara Mendes, Konrad Heinz, Luis Alberto Bezares-Calderón, Elizabeth Williams, Gáspár Jékely
bioRxiv 2020.08.21.260984; doi: https://doi.org/10.1101/2020.08.21.260984

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