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The N34S mutation of SPINK1 may impact the kinetics of trypsinogen activation to cause early trypsin release in the pancreas

Zhuyezi Sun, István Kolossváry, View ORCID ProfileDima Kozakov, Miklós Sahin-Tóth, View ORCID ProfileSandor Vajda
doi: https://doi.org/10.1101/2020.08.21.262162
Zhuyezi Sun
1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215
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István Kolossváry
1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215
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Dima Kozakov
2Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook NY 11794
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Miklós Sahin-Tóth
3Department of Surgery, University of California Los Angeles, Los Angeles, CA 90095
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Sandor Vajda
1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215
4Department of Chemistry, Boston University, Boston, Massachusetts 02215
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  • ORCID record for Sandor Vajda
  • For correspondence: vajda@bu.edu
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Article Information

doi 
https://doi.org/10.1101/2020.08.21.262162
History 
  • August 23, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Zhuyezi Sun1,
  2. István Kolossváry1,
  3. Dima Kozakov2,
  4. Miklós Sahin-Tóth3 and
  5. Sandor Vajda1,4,*
  1. 1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215
  2. 2Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook NY 11794
  3. 3Department of Surgery, University of California Los Angeles, Los Angeles, CA 90095
  4. 4Department of Chemistry, Boston University, Boston, Massachusetts 02215
  1. ↵*Address Correspondence to: Sandor Vajda, Department of Biomedical Engineering, Boston University, 44 Cummington Mall Boston MA 02215, E-mail: vajda{at}bu.edu
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Posted August 23, 2020.
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The N34S mutation of SPINK1 may impact the kinetics of trypsinogen activation to cause early trypsin release in the pancreas
Zhuyezi Sun, István Kolossváry, Dima Kozakov, Miklós Sahin-Tóth, Sandor Vajda
bioRxiv 2020.08.21.262162; doi: https://doi.org/10.1101/2020.08.21.262162
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The N34S mutation of SPINK1 may impact the kinetics of trypsinogen activation to cause early trypsin release in the pancreas
Zhuyezi Sun, István Kolossváry, Dima Kozakov, Miklós Sahin-Tóth, Sandor Vajda
bioRxiv 2020.08.21.262162; doi: https://doi.org/10.1101/2020.08.21.262162

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