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Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy
Evert Njomen, Theresa A. Lansdell, Allison Vanecek, Vanessa Benham, Matt P. Bernard, Ya-Ting Yang, Peter Z. Schall, Daniel Isaac, Omar Alkharabsheh, Anas Al-Janadi, Matthew B. Giletto, Edmund Ellsworth, Catherine Taylor, Terence Tang, Sarah Lau, Marc Bailie, Jamie J. Bernard, Vilma Yuzbasiyan-Gurkan, Jetze J. Tepe
doi: https://doi.org/10.1101/2020.08.24.265470
Evert Njomen
1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Theresa A. Lansdell
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Allison Vanecek
1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States
Vanessa Benham
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Matt P. Bernard
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Ya-Ting Yang
3Comparative Medicine and Integrative Biology Program, Michigan State University, East Lansing, Michigan 48824, United States
Peter Z. Schall
3Comparative Medicine and Integrative Biology Program, Michigan State University, East Lansing, Michigan 48824, United States
Daniel Isaac
4Breslin Cancer Center and Clinical Center, Michigan State University, East Lansing, Michigan 48824, United States
Omar Alkharabsheh
4Breslin Cancer Center and Clinical Center, Michigan State University, East Lansing, Michigan 48824, United States
Anas Al-Janadi
4Breslin Cancer Center and Clinical Center, Michigan State University, East Lansing, Michigan 48824, United States
Matthew B. Giletto
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Edmund Ellsworth
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Catherine Taylor
7Department of Biology, University of Waterloo, ON, Canada
Terence Tang
7Department of Biology, University of Waterloo, ON, Canada
Sarah Lau
7Department of Biology, University of Waterloo, ON, Canada
Marc Bailie
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Jamie J. Bernard
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Vilma Yuzbasiyan-Gurkan
3Comparative Medicine and Integrative Biology Program, Michigan State University, East Lansing, Michigan 48824, United States
5Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, United States
6Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824, United States
Jetze J. Tepe
1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States
2Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan 48824, United States
Posted August 24, 2020.
Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy
Evert Njomen, Theresa A. Lansdell, Allison Vanecek, Vanessa Benham, Matt P. Bernard, Ya-Ting Yang, Peter Z. Schall, Daniel Isaac, Omar Alkharabsheh, Anas Al-Janadi, Matthew B. Giletto, Edmund Ellsworth, Catherine Taylor, Terence Tang, Sarah Lau, Marc Bailie, Jamie J. Bernard, Vilma Yuzbasiyan-Gurkan, Jetze J. Tepe
bioRxiv 2020.08.24.265470; doi: https://doi.org/10.1101/2020.08.24.265470
Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy
Evert Njomen, Theresa A. Lansdell, Allison Vanecek, Vanessa Benham, Matt P. Bernard, Ya-Ting Yang, Peter Z. Schall, Daniel Isaac, Omar Alkharabsheh, Anas Al-Janadi, Matthew B. Giletto, Edmund Ellsworth, Catherine Taylor, Terence Tang, Sarah Lau, Marc Bailie, Jamie J. Bernard, Vilma Yuzbasiyan-Gurkan, Jetze J. Tepe
bioRxiv 2020.08.24.265470; doi: https://doi.org/10.1101/2020.08.24.265470
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