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Epitopes targeted by T cells in convalescent COVID-19 patients

View ORCID ProfileAhmed A. Quadeer, View ORCID ProfileSyed Faraz Ahmed, View ORCID ProfileMatthew R. McKay
doi: https://doi.org/10.1101/2020.08.26.267724
Ahmed A. Quadeer
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
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  • For correspondence: eeaaquadeer@ust.hk m.mckay@ust.hk
Syed Faraz Ahmed
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
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Matthew R. McKay
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
2Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
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  • For correspondence: eeaaquadeer@ust.hk m.mckay@ust.hk
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Abstract

There is growing evidence pointing to the protective role of T cells against COVID-19. Vaccines eliciting targeted T cell responses have the potential to provide robust, long-lasting immunity. However, their design requires knowledge of the SARS-CoV-2-specific epitopes that can elicit a T cell response and confer protection across a wide population. Here, we provide a unified description of emerging data of SARS-CoV-2 T cell epitopes compiled from results of 8 independent studies of convalescent COVID-19 patients. We describe features of these epitopes relevant for vaccine design, while indicating knowledge gaps that can, in part, be augmented using prior immunological data from SARS-CoV. The landscape of SARS-CoV-2 T cell epitopes that we describe can help guide SARS-CoV-2 vaccine development as well as future immunological studies. A web-based platform has also been developed to complement these efforts.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://www.mckayspcb.com/SARS2TcellEpitopes/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 26, 2020.
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Epitopes targeted by T cells in convalescent COVID-19 patients
Ahmed A. Quadeer, Syed Faraz Ahmed, Matthew R. McKay
bioRxiv 2020.08.26.267724; doi: https://doi.org/10.1101/2020.08.26.267724
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Epitopes targeted by T cells in convalescent COVID-19 patients
Ahmed A. Quadeer, Syed Faraz Ahmed, Matthew R. McKay
bioRxiv 2020.08.26.267724; doi: https://doi.org/10.1101/2020.08.26.267724

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