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Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
Ersin Akinci, Minsun Cha, Lin Lin, Grace Yeo, Marisa C. Hamilton, Callie J. Donahue, Heysol C. Bermudez-Cabrera, Larissa C. Zanetti, Maggie Chen, Sammy A. Barkal, Benyapa Khowpinitchai, Nam Chu, Minja Velimirovic, Rikita Jodhani, James D. Fife, Miha Sovrovic, Philip A. Cole, Robert A. Davey, Christopher A. Cassa, Richard I. Sherwood
doi: https://doi.org/10.1101/2020.08.27.270819
Ersin Akinci
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
2Department of Agricultural Biotechnology, Faculty of Agriculture, Akdeniz University, Antalya, 07070, Turkey
Minsun Cha
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Lin Lin
3Hubrecht Institute, 3584 CT Utrecht, the Netherlands
Grace Yeo
4Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Marisa C. Hamilton
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Callie J. Donahue
6Department of Microbiology, National Emerging Infectious Disease Laboratories, Boston University Medical Campus, Boston, MA 02118, USA
Heysol C. Bermudez-Cabrera
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Larissa C. Zanetti
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
7Hospital Israelita Albert Einstein, São Paulo, SP 05652-900, Brazil
Maggie Chen
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
8Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138
Sammy A. Barkal
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Benyapa Khowpinitchai
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Nam Chu
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
9Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
Minja Velimirovic
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
10Centre Hospitalier Universitaire de Québec Research Center–Université Laval, Québec, Québec G1V 4G2, Canada
Rikita Jodhani
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
James D. Fife
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Miha Sovrovic
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Philip A. Cole
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
9Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
Robert A. Davey
6Department of Microbiology, National Emerging Infectious Disease Laboratories, Boston University Medical Campus, Boston, MA 02118, USA
Christopher A. Cassa
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Richard I. Sherwood
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
3Hubrecht Institute, 3584 CT Utrecht, the Netherlands
Article usage
Posted August 28, 2020.
Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
Ersin Akinci, Minsun Cha, Lin Lin, Grace Yeo, Marisa C. Hamilton, Callie J. Donahue, Heysol C. Bermudez-Cabrera, Larissa C. Zanetti, Maggie Chen, Sammy A. Barkal, Benyapa Khowpinitchai, Nam Chu, Minja Velimirovic, Rikita Jodhani, James D. Fife, Miha Sovrovic, Philip A. Cole, Robert A. Davey, Christopher A. Cassa, Richard I. Sherwood
bioRxiv 2020.08.27.270819; doi: https://doi.org/10.1101/2020.08.27.270819
Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
Ersin Akinci, Minsun Cha, Lin Lin, Grace Yeo, Marisa C. Hamilton, Callie J. Donahue, Heysol C. Bermudez-Cabrera, Larissa C. Zanetti, Maggie Chen, Sammy A. Barkal, Benyapa Khowpinitchai, Nam Chu, Minja Velimirovic, Rikita Jodhani, James D. Fife, Miha Sovrovic, Philip A. Cole, Robert A. Davey, Christopher A. Cassa, Richard I. Sherwood
bioRxiv 2020.08.27.270819; doi: https://doi.org/10.1101/2020.08.27.270819
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