Article Information
History
- August 31, 2020.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Mikolaj Zmudzinski1,*,
- Wioletta Rut1,
- Kamila Olech2,
- Jarosław Granda2,
- Mirosław Giurg2,
- Małgorzata Burda-Grabowska2,
- Linlin Zhang3,4,5,
- Xinyuanyuan Sun3,4,5,
- Zongyang Lv6,
- Digant Nayak6,
- Malgorzata Kesik-Brodacka7,
- Shaun K. Olsen6,
- Rolf Hilgenfeld3,5,8 and
- Marcin Drag1,*
- 1Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland
- 2Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wrocław, Poland
- 3Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
- 4Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
- 5German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany
- 6Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 USA
- 7Research Network Łukasiewicz - Institute of Biotechnology and Antibiotics, Starościńska 5, 02-516, Warsaw, Poland
- 8Center for Brain, Behavior and Metabolomics (CBBM), University of Lübeck, 23562 Lübeck, Germany
- ↵*Corresponding author: e-mail address mikolaj.zmudzinski{at}pwr.edu.pl; marcin.drag{at}pwr.edu.pl
Posted August 31, 2020.
Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies
