Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies

Mikolaj Zmudzinski; Wioletta Rut; Kamila Olech; Jarosław Granda; Mirosław Giurg; Małgorzata Burda-Grabowska; Linlin Zhang; Xinyuanyuan Sun; Zongyang Lv; Digant Nayak; Malgorzata Kesik-Brodacka; Shaun K. Olsen; Rolf Hilgenfeld; Marcin Drag

doi:10.1101/2020.08.30.273979

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Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PL^pro and M^pro in in vitro studies

Mikolaj Zmudzinski, Wioletta Rut, Kamila Olech, Jarosław Granda, Mirosław Giurg, Małgorzata Burda-Grabowska, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Malgorzata Kesik-Brodacka, Shaun K. Olsen, View ORCID ProfileRolf Hilgenfeld, View ORCID ProfileMarcin Drag

doi: https://doi.org/10.1101/2020.08.30.273979

Mikolaj Zmudzinski

1Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

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For correspondence: mikolaj.zmudzinski@pwr.edu.pl marcin.drag@pwr.edu.pl

Wioletta Rut

1Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

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Kamila Olech

2Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wrocław, Poland

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Jarosław Granda

2Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wrocław, Poland

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Mirosław Giurg

2Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wrocław, Poland

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Małgorzata Burda-Grabowska

2Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wrocław, Poland

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Linlin Zhang

3Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

4Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

5German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany

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Xinyuanyuan Sun

3Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

4Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

5German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany

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Zongyang Lv

6Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 USA

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Digant Nayak

6Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 USA

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Malgorzata Kesik-Brodacka

7Research Network Łukasiewicz - Institute of Biotechnology and Antibiotics, Starościńska 5, 02-516, Warsaw, Poland

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Shaun K. Olsen

6Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 USA

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Rolf Hilgenfeld

3Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

5German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany

8Center for Brain, Behavior and Metabolomics (CBBM), University of Lübeck, 23562 Lübeck, Germany

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ORCID record for Rolf Hilgenfeld

Marcin Drag

1Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

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ORCID record for Marcin Drag
For correspondence: mikolaj.zmudzinski@pwr.edu.pl marcin.drag@pwr.edu.pl

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Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PL^pro and M^pro in in vitro studies

bioRxiv 2020.08.30.273979; doi: https://doi.org/10.1101/2020.08.30.273979

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Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PL^pro and M^pro in in vitro studies

bioRxiv 2020.08.30.273979; doi: https://doi.org/10.1101/2020.08.30.273979

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