New Results
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
Nir Drayman, Krysten A. Jones, Saara-Anne Azizi, Heather M. Froggatt, Kemin Tan, Natalia Ivanovna Maltseva, Siquan Chen, Vlad Nicolaescu, Steve Dvorkin, Kevin Furlong, Rahul S. Kathayat, Mason R. Firpo, Vincent Mastrodomenico, Emily A. Bruce, Madaline M. Schmidt, Robert Jedrzejczak, Miguel Á. Muñoz-Alía, Brooke Schuster, Vishnu Nair, Jason W. Botten, Christopher B. Brooke, Susan C. Baker, Bryan C. Mounce, Nicholas S. Heaton, Bryan C. Dickinson, Andrzej Jaochimiak, Glenn Randall, Savaş Tay
doi: https://doi.org/10.1101/2020.08.31.274639
Nir Drayman
1The Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA
Krysten A. Jones
2The Department of Chemistry, The University of Chicago, Chicago, IL, USA
Saara-Anne Azizi
2The Department of Chemistry, The University of Chicago, Chicago, IL, USA
Heather M. Froggatt
3The Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA
Kemin Tan
7Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA
8Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
Natalia Ivanovna Maltseva
7Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA
Siquan Chen
5The Cellular Screening Center, The University of Chicago, Chicago, IL, USA
Vlad Nicolaescu
6Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA
Steve Dvorkin
6Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA
Kevin Furlong
6Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA
Rahul S. Kathayat
2The Department of Chemistry, The University of Chicago, Chicago, IL, USA
Mason R. Firpo
15Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Vincent Mastrodomenico
15Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Emily A. Bruce
9Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA
Madaline M. Schmidt
9Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA
10Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA
Robert Jedrzejczak
7Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA
8Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
Miguel Á. Muñoz-Alía
12Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905 USA
Brooke Schuster
1The Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA
Vishnu Nair
1The Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA
Jason W. Botten
9Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA
10Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA
11Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, 05405 USA
Christopher B. Brooke
13Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
14Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
Susan C. Baker
15Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Bryan C. Mounce
15Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Nicholas S. Heaton
3The Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA
Bryan C. Dickinson
2The Department of Chemistry, The University of Chicago, Chicago, IL, USA
Andrzej Jaochimiak
4The Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA
7Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA
8Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
Glenn Randall
6Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA
Savaş Tay
1The Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA
Posted September 01, 2020.
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
Nir Drayman, Krysten A. Jones, Saara-Anne Azizi, Heather M. Froggatt, Kemin Tan, Natalia Ivanovna Maltseva, Siquan Chen, Vlad Nicolaescu, Steve Dvorkin, Kevin Furlong, Rahul S. Kathayat, Mason R. Firpo, Vincent Mastrodomenico, Emily A. Bruce, Madaline M. Schmidt, Robert Jedrzejczak, Miguel Á. Muñoz-Alía, Brooke Schuster, Vishnu Nair, Jason W. Botten, Christopher B. Brooke, Susan C. Baker, Bryan C. Mounce, Nicholas S. Heaton, Bryan C. Dickinson, Andrzej Jaochimiak, Glenn Randall, Savaş Tay
bioRxiv 2020.08.31.274639; doi: https://doi.org/10.1101/2020.08.31.274639
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
Nir Drayman, Krysten A. Jones, Saara-Anne Azizi, Heather M. Froggatt, Kemin Tan, Natalia Ivanovna Maltseva, Siquan Chen, Vlad Nicolaescu, Steve Dvorkin, Kevin Furlong, Rahul S. Kathayat, Mason R. Firpo, Vincent Mastrodomenico, Emily A. Bruce, Madaline M. Schmidt, Robert Jedrzejczak, Miguel Á. Muñoz-Alía, Brooke Schuster, Vishnu Nair, Jason W. Botten, Christopher B. Brooke, Susan C. Baker, Bryan C. Mounce, Nicholas S. Heaton, Bryan C. Dickinson, Andrzej Jaochimiak, Glenn Randall, Savaş Tay
bioRxiv 2020.08.31.274639; doi: https://doi.org/10.1101/2020.08.31.274639
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