UHRF1 suppresses viral mimicry through both DNA methylation-dependent and -independent mechanisms

RE Irwin; CA Scullion; SJ Thursby; ML Sun; A Thakur; SB Rothbart; GL Xu; CP Walsh

doi:10.1101/2020.08.31.274894

Article Information

doi

https://doi.org/10.1101/2020.08.31.274894

History

August 31, 2020.

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

RE Irwin1,
CA Scullion4,
SJ Thursby1,
ML Sun2,
A Thakur1,5,
SB Rothbart4,
GL Xu2,3 and
CP Walsh1,*

¹Genomic Medicine Research Group, Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, UK
²Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
³Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University & Chinese Academy of Medical Sciences (RU069), Shanghai, China
⁴Van Andel Research Institute, 333 Bostwick Ave, Grand Rapids, MI 49503, USA
⁵Terry Fox Laboratory & Dept. of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, Canada