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Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
Jessica A. Plante, Yang Liu, Jianying Liu, Hongjie Xia, Bryan A. Johnson, Kumari G. Lokugamage, Xianwen Zhang, Antonio E. Muruato, Jing Zou, Camila R. Fontes-Garfias, Divya Mirchandani, Dionna Scharton, John P. Bilello, Zhiqiang Ku, Zhiqiang An, Birte Kalveram, Alexander N. Freiberg, Vineet D. Menachery, Xuping Xie, Kenneth S. Plante, Scott C. Weaver, Pei-Yong Shi
doi: https://doi.org/10.1101/2020.09.01.278689
Jessica A. Plante
1World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston TX, USA
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
Yang Liu
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA
Jianying Liu
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
Hongjie Xia
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA
Bryan A. Johnson
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
Kumari G. Lokugamage
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
Xianwen Zhang
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA
Antonio E. Muruato
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
Jing Zou
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA
Camila R. Fontes-Garfias
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA
Divya Mirchandani
1World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston TX, USA
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
Dionna Scharton
1World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston TX, USA
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
John P. Bilello
5Gilead Sciences, Inc., Foster City, CA, USA
Zhiqiang Ku
6Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, USA
Zhiqiang An
6Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, USA
Birte Kalveram
7Department of Pathology, University of Texas Medical Branch, Galveston TX, USA
Alexander N. Freiberg
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
7Department of Pathology, University of Texas Medical Branch, Galveston TX, USA
9Center for Biodefense & Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA
10Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA
Vineet D. Menachery
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
Xuping Xie
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA
Kenneth S. Plante
1World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston TX, USA
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
Scott C. Weaver
1World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston TX, USA
2Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston TX, USA
3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, USA
8Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USA
9Center for Biodefense & Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA
10Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA
Pei-Yong Shi
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA
8Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USA
9Center for Biodefense & Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA
10Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA
11Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA
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Posted September 02, 2020.
Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
Jessica A. Plante, Yang Liu, Jianying Liu, Hongjie Xia, Bryan A. Johnson, Kumari G. Lokugamage, Xianwen Zhang, Antonio E. Muruato, Jing Zou, Camila R. Fontes-Garfias, Divya Mirchandani, Dionna Scharton, John P. Bilello, Zhiqiang Ku, Zhiqiang An, Birte Kalveram, Alexander N. Freiberg, Vineet D. Menachery, Xuping Xie, Kenneth S. Plante, Scott C. Weaver, Pei-Yong Shi
bioRxiv 2020.09.01.278689; doi: https://doi.org/10.1101/2020.09.01.278689
Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
Jessica A. Plante, Yang Liu, Jianying Liu, Hongjie Xia, Bryan A. Johnson, Kumari G. Lokugamage, Xianwen Zhang, Antonio E. Muruato, Jing Zou, Camila R. Fontes-Garfias, Divya Mirchandani, Dionna Scharton, John P. Bilello, Zhiqiang Ku, Zhiqiang An, Birte Kalveram, Alexander N. Freiberg, Vineet D. Menachery, Xuping Xie, Kenneth S. Plante, Scott C. Weaver, Pei-Yong Shi
bioRxiv 2020.09.01.278689; doi: https://doi.org/10.1101/2020.09.01.278689
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