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Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly
Alice Lanne, View ORCID ProfileYixin Cui, Edward Browne, View ORCID ProfilePhilip G. E. Craven, View ORCID ProfileNicholas J. Cundy, View ORCID ProfileNicholas J. Coltman, Katie Dale, View ORCID ProfileAntonio Feula, View ORCID ProfileJon Frampton, Aaron Goff, View ORCID ProfileMariwan A. Hama Salih, Xingfen Lang, View ORCID ProfileXingjian Li, Christopher W. Moon, View ORCID ProfileMichael Morton, Jordan Pascoe, View ORCID ProfileXudan Peng, Vanessa Portman, View ORCID ProfileCara Press, Timothy Schulz-Utermoehl, Micky Tortorella, Zhengchao Tu, Zoe E. Underwood, View ORCID ProfileChangwei Wang, View ORCID ProfileAkina Yoshizawa, View ORCID ProfileTianyu Zhang, View ORCID ProfileSimon J Waddell, View ORCID ProfileJoanna Bacon, View ORCID ProfileCleopatra Neagoie, View ORCID ProfileJohn S. Fossey, View ORCID ProfileLuke J. Alderwick.
doi: https://doi.org/10.1101/2020.09.03.281170
Alice Lanne
aInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Yixin Cui
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Edward Browne
cSygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham, UK
Philip G. E. Craven
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Nicholas J. Cundy
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Nicholas J. Coltman
dSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Katie Dale
aInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Antonio Feula
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Jon Frampton
eCollege of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Aaron Goff
fDepartment of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer, BN1 9PX, UK
Mariwan A. Hama Salih
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Xingfen Lang
gGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou, China
Xingjian Li
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
gGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou, China
Christopher W. Moon
hTB Research Group, National Infection Service, Public Health England, Manor Farm Road, Porton, Salisbury SP4 0JG, UK
Michael Morton
iApconiX Ltd, BIOHUB at Alderly Park, Nether Alderly, Cheshire, SK10 4TG, UK
Jordan Pascoe
hTB Research Group, National Infection Service, Public Health England, Manor Farm Road, Porton, Salisbury SP4 0JG, UK
Xudan Peng
gGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou, China
Vanessa Portman
cSygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham, UK
Cara Press
aInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Timothy Schulz-Utermoehl
cSygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham, UK
Micky Tortorella
gGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou, China
jLegion Pharma, Kai Yuan Avenue, Science Park, Guangzhou, China
Zhengchao Tu
gGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou, China
Zoe E. Underwood
hTB Research Group, National Infection Service, Public Health England, Manor Farm Road, Porton, Salisbury SP4 0JG, UK
Changwei Wang
kState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou 510530, China
Akina Yoshizawa
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Tianyu Zhang
kState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou 510530, China
lUniversity of Chinese Academy of Sciences (UCAS), Beijing 100049, China
Simon J Waddell
fDepartment of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer, BN1 9PX, UK
Joanna Bacon
hTB Research Group, National Infection Service, Public Health England, Manor Farm Road, Porton, Salisbury SP4 0JG, UK
Cleopatra Neagoie
gGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou, China
mVisiting Scientist, School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
John S. Fossey
bSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Luke J. Alderwick.
aInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
Article usage
Posted September 03, 2020.
Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly
Alice Lanne, Yixin Cui, Edward Browne, Philip G. E. Craven, Nicholas J. Cundy, Nicholas J. Coltman, Katie Dale, Antonio Feula, Jon Frampton, Aaron Goff, Mariwan A. Hama Salih, Xingfen Lang, Xingjian Li, Christopher W. Moon, Michael Morton, Jordan Pascoe, Xudan Peng, Vanessa Portman, Cara Press, Timothy Schulz-Utermoehl, Micky Tortorella, Zhengchao Tu, Zoe E. Underwood, Changwei Wang, Akina Yoshizawa, Tianyu Zhang, Simon J Waddell, Joanna Bacon, Cleopatra Neagoie, John S. Fossey, Luke J. Alderwick.
bioRxiv 2020.09.03.281170; doi: https://doi.org/10.1101/2020.09.03.281170
Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly
Alice Lanne, Yixin Cui, Edward Browne, Philip G. E. Craven, Nicholas J. Cundy, Nicholas J. Coltman, Katie Dale, Antonio Feula, Jon Frampton, Aaron Goff, Mariwan A. Hama Salih, Xingfen Lang, Xingjian Li, Christopher W. Moon, Michael Morton, Jordan Pascoe, Xudan Peng, Vanessa Portman, Cara Press, Timothy Schulz-Utermoehl, Micky Tortorella, Zhengchao Tu, Zoe E. Underwood, Changwei Wang, Akina Yoshizawa, Tianyu Zhang, Simon J Waddell, Joanna Bacon, Cleopatra Neagoie, John S. Fossey, Luke J. Alderwick.
bioRxiv 2020.09.03.281170; doi: https://doi.org/10.1101/2020.09.03.281170
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