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Combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
View ORCID ProfileFriedel Drepper, Jacek Biernat, View ORCID ProfileSenthillvelrajan Kaniyappan, Helmut E. Meyer, Eva Maria Mandelkow, View ORCID ProfileBettina Warscheid, View ORCID ProfileEckhard Mandelkow
doi: https://doi.org/10.1101/2020.09.03.281907
Friedel Drepper
1Biochemistry and Functional Proteomics, Institute of Biology II, University of Freiburg, Schänzlestr. 1, 79104 Freiburg, Germany
2Signalling Research Centres BIOSS and CIBSS, University of Freiburg
Jacek Biernat
3DZNE (German Center for Neurodegenerative Diseases), Venusberg-Campus 1, Building 99, 53127 Bonn, Germany
Senthillvelrajan Kaniyappan
3DZNE (German Center for Neurodegenerative Diseases), Venusberg-Campus 1, Building 99, 53127 Bonn, Germany
4Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Venusberg-Campus 1, Building 82, 53127 Bonn, Germany
Helmut E. Meyer
5Medical Proteome -Center, Ruhr-University Bochum, Universitätsstraße 150, 44801 Bochum, Germany
6Leibniz-Institute für Analytical Sciences (ISAS), Biomedical Research Dortmund, Germany
Eva Maria Mandelkow
3DZNE (German Center for Neurodegenerative Diseases), Venusberg-Campus 1, Building 99, 53127 Bonn, Germany
7CAESAR Research Center, Ludwig-Erhard-Allee 2, 53127 Bonn, Germany
Bettina Warscheid
1Biochemistry and Functional Proteomics, Institute of Biology II, University of Freiburg, Schänzlestr. 1, 79104 Freiburg, Germany
2Signalling Research Centres BIOSS and CIBSS, University of Freiburg
Eckhard Mandelkow
3DZNE (German Center for Neurodegenerative Diseases), Venusberg-Campus 1, Building 99, 53127 Bonn, Germany
7CAESAR Research Center, Ludwig-Erhard-Allee 2, 53127 Bonn, Germany
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Posted September 04, 2020.
Combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
Friedel Drepper, Jacek Biernat, Senthillvelrajan Kaniyappan, Helmut E. Meyer, Eva Maria Mandelkow, Bettina Warscheid, Eckhard Mandelkow
bioRxiv 2020.09.03.281907; doi: https://doi.org/10.1101/2020.09.03.281907
Combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
Friedel Drepper, Jacek Biernat, Senthillvelrajan Kaniyappan, Helmut E. Meyer, Eva Maria Mandelkow, Bettina Warscheid, Eckhard Mandelkow
bioRxiv 2020.09.03.281907; doi: https://doi.org/10.1101/2020.09.03.281907
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