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Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5

Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, View ORCID ProfileRong Huang
doi: https://doi.org/10.1101/2020.09.05.283978
Ayad A. Al-Hamashi
aDepartment of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, United States
bDepartment of Pharmaceutical Chemistry, College of Pharmacy, Bab-almoadham, Baghdad, Iraq
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Dongxing Chen
aDepartment of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, United States
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Youchao Deng
aDepartment of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, United States
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Guangping Dong
aDepartment of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, United States
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Rong Huang
aDepartment of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, United States
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  • ORCID record for Rong Huang
  • For correspondence: huang-r@purdue.edu
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Article Information

doi 
https://doi.org/10.1101/2020.09.05.283978
History 
  • September 6, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Ayad A. Al-Hamashia,b,
  2. Dongxing Chena,
  3. Youchao Denga,
  4. Guangping Donga and
  5. Rong Huanga,*
  1. aDepartment of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, United States
  2. bDepartment of Pharmaceutical Chemistry, College of Pharmacy, Bab-almoadham, Baghdad, Iraq
  1. ↵*Address correspondence to this author at the Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 720 Clinic Drive, West Lafayette, Indiana, 47907, USA; Tel: +001-765-494-3426; E-mail: huang-r{at}purdue.edu
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Posted September 06, 2020.
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Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5
Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
bioRxiv 2020.09.05.283978; doi: https://doi.org/10.1101/2020.09.05.283978
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Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5
Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
bioRxiv 2020.09.05.283978; doi: https://doi.org/10.1101/2020.09.05.283978

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