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Population receptive fields in non-human primates from whole-brain fMRI and large-scale neurophysiology in visual cortex

View ORCID ProfileP. Christiaan Klink, Xing Chen, View ORCID ProfileWim Vanduffel, View ORCID ProfilePieter R. Roelfsema
doi: https://doi.org/10.1101/2020.09.05.284133
P. Christiaan Klink
1Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
2Psychiatry Department, Amsterdam UMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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  • For correspondence: c.klink@nin.knaw.nl
Xing Chen
1Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
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Wim Vanduffel
3Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000, Leuven, Belgium
4Massachusetts General Hospital, Martinos Ctr. for Biomedical Imaging, Charlestown, MA, 02129, USA
5Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium
6Harvard Medical School, Boston, MA, 02115, USA
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Pieter R. Roelfsema
1Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
2Psychiatry Department, Amsterdam UMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
7Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
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Abstract

Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF-maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake non-human primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF-models based on the fMRI BOLD-signal, multi-unit spiking activity (MUA) and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. FMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF-size with increasing eccentricity, as well as a retinotopically specific deactivation of default-mode network nodes similar to previous observations in humans.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Ethics statement

    Animal care and experimental procedures were in accordance with the ILAR’s Guide for the Care and Use of Laboratory Animals, the European legislation (Directive 2010/63/EU) and approved by the institutional animal care and use committee of the Royal Netherlands Academy of Arts and Sciences and the Central Authority for Scientific Procedures on Animals (CCD) in the Netherlands.

  • Conflicts of interest

    The authors declare that no financial or non-financial competing interests exist.

  • Data and code availability

    All data and code are available on GIN: https://doi.org/10.12751/g-node.p8ypgv,

    Unthresholded fMRI model fitting results are on Neurovault: https://identifiers.org/neurovault.collection:8082

  • This is a revision of the paper in response to reviewer questions and comments at eLife.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted October 13, 2021.
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Population receptive fields in non-human primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
P. Christiaan Klink, Xing Chen, Wim Vanduffel, Pieter R. Roelfsema
bioRxiv 2020.09.05.284133; doi: https://doi.org/10.1101/2020.09.05.284133
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Population receptive fields in non-human primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
P. Christiaan Klink, Xing Chen, Wim Vanduffel, Pieter R. Roelfsema
bioRxiv 2020.09.05.284133; doi: https://doi.org/10.1101/2020.09.05.284133

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