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Cooperative efforts on developing vaccines and therapies for COVID-19 Cooperative efforts for COVID-19

View ORCID ProfileFernanda Gisele Basso, View ORCID ProfileAlex Fabianne de Paulo, View ORCID ProfileGeciane Silveira Porto, View ORCID ProfileCristiano Gonçalves Pereira
doi: https://doi.org/10.1101/2020.09.06.282145
Fernanda Gisele Basso
1Institute of Advanced Studies of the University of São Paulo. Ribeirão Preto - State of São Paulo, Brazil
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Alex Fabianne de Paulo
2School of Information and Communication, Federal University of Goiás. Goiânia - State of Goiás, Brazil
1Institute of Advanced Studies of the University of São Paulo. Ribeirão Preto - State of São Paulo, Brazil
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Geciane Silveira Porto
3School of Economics, Business Administration and Accounting, University of São Paulo
1Institute of Advanced Studies of the University of São Paulo. Ribeirão Preto - State of São Paulo, Brazil
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  • For correspondence: geciane@usp.br
Cristiano Gonçalves Pereira
4Strategic Partnerships and Business Development Office, Butantan Institute
1Institute of Advanced Studies of the University of São Paulo. Ribeirão Preto - State of São Paulo, Brazil
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Abstract

Health organizations have always sought partnership to join competencies in innovation, even with fierce competition in this sector. In this pandemic moment it is relevant to observe how organizations behave to seek quick and safe answers. The present research analyzes how the cooperation networks were set off considering the clinical trials on therapies and vaccines that were developed specifically to treat or prevent COVID-19. Social Network Analysis technique was used to build cooperation networks and apply metrics that characterize these connections. There was an evaluation of statistics of Strength of cooperation and Unilateral dependence of cooperation that identify the cooperation strength between two organizations, and the dependence of this relations. A total of 415 clinical trial were identified, of which 42% are in cooperation. From organizations that have partnership, firms are the first, followed by universities. We extracted the main categories that concentrate 74% of partnerships in the trials of antibody, and vaccine. Several organizations cooperate in multiple categories of trials, evidencing the efforts to focus on different strategies to treat the disease. We found high strength of cooperation and an assimetryc dependency between partners, which can be assigned to specialized models of partnership and it occurs in competitive enviroments like this pandemic moment. Cooperation were not limited to geographical proximity and the advent of Chinese players can represent a new change in the biotechnological development axis. Finally, the challenge of finding therapeutic or immunological solutions for COVID-19 demonstrates a clear composition of cooperation groups that complement their skills to manage organizational strategies to beat the pandemic. In this new paradigm, there can be partnerships not only in clinical trial but also in pre-competitive technologies development. This experience is expected to change the way of organizations define their R&D strategies and start to adopt more a collaborative innovation model.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted September 06, 2020.
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Cooperative efforts on developing vaccines and therapies for COVID-19 Cooperative efforts for COVID-19
Fernanda Gisele Basso, Alex Fabianne de Paulo, Geciane Silveira Porto, Cristiano Gonçalves Pereira
bioRxiv 2020.09.06.282145; doi: https://doi.org/10.1101/2020.09.06.282145
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Cooperative efforts on developing vaccines and therapies for COVID-19 Cooperative efforts for COVID-19
Fernanda Gisele Basso, Alex Fabianne de Paulo, Geciane Silveira Porto, Cristiano Gonçalves Pereira
bioRxiv 2020.09.06.282145; doi: https://doi.org/10.1101/2020.09.06.282145

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