New Results
Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo
Qian Wang, Yi F. Guan, Sarah E. Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K. Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Lisa G. Horvath, Nigel Turner, View ORCID ProfileJeff Holst
doi: https://doi.org/10.1101/2020.09.07.286997
Qian Wang
1Translational Cancer Metabolism Laboratory, School of Medical Sciences and Prince of Wales Clinical School, UNSW Sydney, Australia
Yi F. Guan
1Translational Cancer Metabolism Laboratory, School of Medical Sciences and Prince of Wales Clinical School, UNSW Sydney, Australia
Sarah E. Hancock
2Mitochondrial Bioenergetics Laboratory, Department of Pharmacology, School of Medical Sciences, UNSW Sydney, Sydney, Australia
Kanu Wahi
1Translational Cancer Metabolism Laboratory, School of Medical Sciences and Prince of Wales Clinical School, UNSW Sydney, Australia
Michelle van Geldermalsen
3Origins of Cancer Program, Centenary Institute, University of Sydney, Camperdown, New South Wales, Australia
4Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Blake K. Zhang
3Origins of Cancer Program, Centenary Institute, University of Sydney, Camperdown, New South Wales, Australia
4Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Angel Pang
1Translational Cancer Metabolism Laboratory, School of Medical Sciences and Prince of Wales Clinical School, UNSW Sydney, Australia
Rajini Nagarajah
3Origins of Cancer Program, Centenary Institute, University of Sydney, Camperdown, New South Wales, Australia
4Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Blossom Mak
5Chris O’Brien Lifehouse, Sydney, Australia; Garvan Institute of Medical Research, Sydney, Australia; University of NSW, Sydney, Australia; University of Sydney, Sydney, Australia
Lisa G. Horvath
5Chris O’Brien Lifehouse, Sydney, Australia; Garvan Institute of Medical Research, Sydney, Australia; University of NSW, Sydney, Australia; University of Sydney, Sydney, Australia
Nigel Turner
2Mitochondrial Bioenergetics Laboratory, Department of Pharmacology, School of Medical Sciences, UNSW Sydney, Sydney, Australia
Jeff Holst
1Translational Cancer Metabolism Laboratory, School of Medical Sciences and Prince of Wales Clinical School, UNSW Sydney, Australia
Article usage
Posted September 09, 2020.
Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo
Qian Wang, Yi F. Guan, Sarah E. Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K. Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Lisa G. Horvath, Nigel Turner, Jeff Holst
bioRxiv 2020.09.07.286997; doi: https://doi.org/10.1101/2020.09.07.286997
Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo
Qian Wang, Yi F. Guan, Sarah E. Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K. Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Lisa G. Horvath, Nigel Turner, Jeff Holst
bioRxiv 2020.09.07.286997; doi: https://doi.org/10.1101/2020.09.07.286997
Subject Area
Subject Areas
- Biochemistry (11730)
- Bioengineering (8743)
- Bioinformatics (29179)
- Biophysics (14964)
- Cancer Biology (12080)
- Cell Biology (17399)
- Clinical Trials (138)
- Developmental Biology (9417)
- Ecology (14174)
- Epidemiology (2067)
- Evolutionary Biology (18294)
- Genetics (12233)
- Genomics (16791)
- Immunology (11858)
- Microbiology (28051)
- Molecular Biology (11575)
- Neuroscience (60919)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4955)
- Plant Biology (10422)
- Synthetic Biology (2881)
- Systems Biology (7338)
- Zoology (1650)