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Evolution of kinase polypharmacology across HSP90 drug discovery

View ORCID ProfileAlbert A. Antolin, View ORCID ProfilePaul A. Clarke, Ian Collins, View ORCID ProfilePaul Workman, View ORCID ProfileBissan Al-Lazikani
doi: https://doi.org/10.1101/2020.09.09.288936
Albert A. Antolin
1Department of Data Science, The Institute of Cancer Research, London, SM2 5NG, UK
2Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK
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  • ORCID record for Albert A. Antolin
  • For correspondence: Albert.Antolin@icr.ac.uk Paul.Workman@icr.ac.uk Bissan.Al-Lazikani@icr.ac.uk
Paul A. Clarke
2Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK
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Ian Collins
2Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK
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Paul Workman
2Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK
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  • For correspondence: Albert.Antolin@icr.ac.uk Paul.Workman@icr.ac.uk Bissan.Al-Lazikani@icr.ac.uk
Bissan Al-Lazikani
1Department of Data Science, The Institute of Cancer Research, London, SM2 5NG, UK
2Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK
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  • ORCID record for Bissan Al-Lazikani
  • For correspondence: Albert.Antolin@icr.ac.uk Paul.Workman@icr.ac.uk Bissan.Al-Lazikani@icr.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2020.09.09.288936
History 
  • September 10, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Albert A. Antolin1,2,*,
  2. Paul A. Clarke2,
  3. Ian Collins2,
  4. Paul Workman2,* and
  5. Bissan Al-Lazikani1,2,3,*
  1. 1Department of Data Science, The Institute of Cancer Research, London, SM2 5NG, UK
  2. 2Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK
  1. ↵*Correspondence: Albert.Antolin{at}icr.ac.uk (A.A.A.), Paul.Workman{at}icr.ac.uk (P.W.), Bissan.Al-Lazikani{at}icr.ac.uk (B.A.-L.).
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Evolution of kinase polypharmacology across HSP90 drug discovery
Albert A. Antolin, Paul A. Clarke, Ian Collins, Paul Workman, Bissan Al-Lazikani
bioRxiv 2020.09.09.288936; doi: https://doi.org/10.1101/2020.09.09.288936
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Evolution of kinase polypharmacology across HSP90 drug discovery
Albert A. Antolin, Paul A. Clarke, Ian Collins, Paul Workman, Bissan Al-Lazikani
bioRxiv 2020.09.09.288936; doi: https://doi.org/10.1101/2020.09.09.288936

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