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Susceptibility of domestic swine to experimental infection with SARS-CoV-2

Brad S. Pickering, Greg Smith, Mathieu M. Pinette, Carissa Embury-Hyatt, Estella Moffat, Peter Marszal, Charles E. Lewis
doi: https://doi.org/10.1101/2020.09.10.288548
Brad S. Pickering
1Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada
2University of Manitoba, Winnipeg, Canada
3Iowa State University, Ames Iowa, United States of America
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  • For correspondence: bradley.pickering@canada.ca
Greg Smith
1Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada
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Mathieu M. Pinette
1Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada
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Carissa Embury-Hyatt
1Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada
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Estella Moffat
1Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada
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Peter Marszal
1Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada
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Charles E. Lewis
3Iowa State University, Ames Iowa, United States of America
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Abstract

SARS-CoV-2, the agent responsible for COVID-19 has been shown to infect a number of species. The role of domestic livestock and the risk associated for humans in close contact remains unknown for many production animals. Determination of the susceptibility of pigs to SARS-CoV-2 is critical towards a One Health approach to manage the potential risk of zoonotic transmission. Here, pigs undergoing experimental inoculation are susceptible to SARS-CoV-2 at low levels. Viral RNA was detected in group oral fluids and nasal wash from at least two animals while live virus was isolated from a pig. Further, antibodies could be detected in two animals at 11 and 13 days post infection, while oral fluid samples at 6 days post inoculation indicated the presence of secreted antibodies. These data highlight the need for additional livestock assessment to better determine the potential role domestic animals may contribute towards the SARS-CoV-2 pandemic.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 10, 2020.
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Susceptibility of domestic swine to experimental infection with SARS-CoV-2
Brad S. Pickering, Greg Smith, Mathieu M. Pinette, Carissa Embury-Hyatt, Estella Moffat, Peter Marszal, Charles E. Lewis
bioRxiv 2020.09.10.288548; doi: https://doi.org/10.1101/2020.09.10.288548
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Susceptibility of domestic swine to experimental infection with SARS-CoV-2
Brad S. Pickering, Greg Smith, Mathieu M. Pinette, Carissa Embury-Hyatt, Estella Moffat, Peter Marszal, Charles E. Lewis
bioRxiv 2020.09.10.288548; doi: https://doi.org/10.1101/2020.09.10.288548

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