Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

Emma Garst; Hwayoung Lee; Tandrila Das; Shibani Bhattacharya; Avital Percher; Rafal Wiewiora; Isaac P. Witte; Yumeng Li; Michael Goger; Tao Peng; Wonpil Im; Howard C. Hang

doi:10.1101/2020.09.11.293324

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Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

View ORCID ProfileEmma Garst, Hwayoung Lee, Tandrila Das, Shibani Bhattacharya, Avital Percher, Rafal Wiewiora, Isaac P. Witte, Yumeng Li, Michael Goger, Tao Peng, Wonpil Im, View ORCID ProfileHoward C. Hang

doi: https://doi.org/10.1101/2020.09.11.293324

Emma Garst

1Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065, United States

2Tri-Institutional Ph.D. Program in Chemical Biology, New York, NY 10065, United States

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ORCID record for Emma Garst

Hwayoung Lee

3Department of Biological Sciences, Chemistry, and Bioengineering, Lehigh University, Bethlehem, PA 18015, United States

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Tandrila Das

1Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065, United States

2Tri-Institutional Ph.D. Program in Chemical Biology, New York, NY 10065, United States

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Shibani Bhattacharya

4New York Structural Biology Center, New York, NY 10027, United States

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Avital Percher

1Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065, United States

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Rafal Wiewiora

2Tri-Institutional Ph.D. Program in Chemical Biology, New York, NY 10065, United States

5Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States

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Isaac P. Witte

1Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065, United States

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Yumeng Li

6State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China

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Michael Goger

4New York Structural Biology Center, New York, NY 10027, United States

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Tao Peng

6State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China

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Wonpil Im

3Department of Biological Sciences, Chemistry, and Bioengineering, Lehigh University, Bethlehem, PA 18015, United States

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Howard C. Hang

1Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065, United States

7Departments of Immunology and Microbiology and Chemistry, Scripps Research, La Jolla, CA 92037, United States

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ORCID record for Howard C. Hang
For correspondence: hhang@scripps.edu

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Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

Emma Garst, Hwayoung Lee, Tandrila Das, Shibani Bhattacharya, Avital Percher, Rafal Wiewiora, Isaac P. Witte, Yumeng Li, Michael Goger, Tao Peng, Wonpil Im, Howard C. Hang

bioRxiv 2020.09.11.293324; doi: https://doi.org/10.1101/2020.09.11.293324

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Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

Emma Garst, Hwayoung Lee, Tandrila Das, Shibani Bhattacharya, Avital Percher, Rafal Wiewiora, Isaac P. Witte, Yumeng Li, Michael Goger, Tao Peng, Wonpil Im, Howard C. Hang

bioRxiv 2020.09.11.293324; doi: https://doi.org/10.1101/2020.09.11.293324

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