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Citrullination of proteins as a specific response mechanism in plants

Claudius Marondedze, Giuliano Elia, Ludivine Thomas, View ORCID ProfileAloysius Wong, View ORCID ProfileChris Gehring
doi: https://doi.org/10.1101/2020.09.12.294728
Claudius Marondedze
1Division of Biological and Chemical Science and Engineering, 4700 King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
2Rijk Zwaan, De Lier 2678 ZG, Netherlands
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Giuliano Elia
3Philochem AG, Libernstrasse, CH-8112 Otelfingen, Switzerland
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Ludivine Thomas
1Division of Biological and Chemical Science and Engineering, 4700 King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
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Aloysius Wong
4Department of Biology, College of Science and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou, Zhejiang Province 325060, China
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Chris Gehring
1Division of Biological and Chemical Science and Engineering, 4700 King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
5Department of Chemistry, Biology & Biotechnology, University of Perugia, I-06121 Perugia, Italy
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  • For correspondence: christophandreas.gehring@UniPG.it
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ABSTRACT

Arginine deamination, also referred to as citrullination of proteins by peptidyl-arginine deiminases, is a post-translational modification affecting histone modifications, epigenetic transcriptional regulation and proteolysis in animals, but has not been reported in higher plants. Here we report, firstly, that Arabidopsis thaliana proteome contains proteins with a specific citrullination signature and that many of the citrullinated proteins have nucleotide-binding regulatory functions. Secondly, we show that changes in the citrullinome occur in response to cold stress, and thirdly, we identify an Arabidopsis thaliana protein with calcium-dependent arginine deiminase activity. Taken together, these findings establish this post-translational modification as a hitherto neglected component of cellular reprogramming during stress responses.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 21, 2020.
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Citrullination of proteins as a specific response mechanism in plants
Claudius Marondedze, Giuliano Elia, Ludivine Thomas, Aloysius Wong, Chris Gehring
bioRxiv 2020.09.12.294728; doi: https://doi.org/10.1101/2020.09.12.294728
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Citrullination of proteins as a specific response mechanism in plants
Claudius Marondedze, Giuliano Elia, Ludivine Thomas, Aloysius Wong, Chris Gehring
bioRxiv 2020.09.12.294728; doi: https://doi.org/10.1101/2020.09.12.294728

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