Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

Angad Malhotra, Matthias Walle, Graeme R. Paul, Gisela A. Kuhn, View ORCID ProfileRalph Müller
doi: https://doi.org/10.1101/2020.09.13.295402
Angad Malhotra
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias Walle
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Graeme R. Paul
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gisela A. Kuhn
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralph Müller
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ralph Müller
  • For correspondence: ram@ethz.ch
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the application of mechanical stimulation across a bone defect could improve healing. However, if ignoring the mechanical integrity of defected bone, loading regimes have a high potential to either cause damage or be ineffective. This study explores real-time finite element (rtFE) methods that use three-dimensional structural analyses from micro-computed tomography images to estimate effective peak cyclic loads in a subject-specific and time-dependent manner. It demonstrates the concept in a cyclically loaded mouse caudal vertebral bone defect model. Using rtFE analysis combined with adaptive mechanical loading, mouse bone healing was significantly improved over non-loaded controls, with no incidence of vertebral fractures. Such rtFE-driven adaptive loading regimes demonstrated here could be relevant to clinical bone defect healing scenarios, where mechanical loading can become patient-specific and more efficacious. This is achieved by accounting for initial bone defect conditions and spatio-temporal healing, both being factors that are always unique to the patient.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • The title was reworded again and a portion of text was also added (l.265 onwards). Both as requested by Scientific Reports

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted January 10, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
Angad Malhotra, Matthias Walle, Graeme R. Paul, Gisela A. Kuhn, Ralph Müller
bioRxiv 2020.09.13.295402; doi: https://doi.org/10.1101/2020.09.13.295402
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
Angad Malhotra, Matthias Walle, Graeme R. Paul, Gisela A. Kuhn, Ralph Müller
bioRxiv 2020.09.13.295402; doi: https://doi.org/10.1101/2020.09.13.295402

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioengineering
Subject Areas
All Articles
  • Animal Behavior and Cognition (2410)
  • Biochemistry (4763)
  • Bioengineering (3307)
  • Bioinformatics (14600)
  • Biophysics (6598)
  • Cancer Biology (5138)
  • Cell Biology (7387)
  • Clinical Trials (138)
  • Developmental Biology (4328)
  • Ecology (6834)
  • Epidemiology (2057)
  • Evolutionary Biology (9854)
  • Genetics (7317)
  • Genomics (9478)
  • Immunology (4515)
  • Microbiology (12603)
  • Molecular Biology (4907)
  • Neuroscience (28142)
  • Paleontology (198)
  • Pathology (799)
  • Pharmacology and Toxicology (1373)
  • Physiology (2000)
  • Plant Biology (4458)
  • Scientific Communication and Education (970)
  • Synthetic Biology (1293)
  • Systems Biology (3896)
  • Zoology (719)