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The Anti-histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits SARS-CoV-2 Infection in Reconstituted Human Nasal Tissue In Vitro

View ORCID ProfileRobert Konrat, Henrietta Papp, Valéria Szijártó, Tanja Gesell, Gábor Nagy, Mónika Madai, Safia Zeghbib, Anett Kuczmog, Zsófia Lanszki, Zsuzsanna Helyes, Gábor Kemenesi, Ferenc Jakab, Eszter Nagy
doi: https://doi.org/10.1101/2020.09.15.296228
Robert Konrat
aDepartment of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, A-1030 Vienna, Austria
bCalyxha Biotechnologies GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
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  • ORCID record for Robert Konrat
  • For correspondence: robert.konrat@univie.ac.at eszter.nagy@cebina.eu
Henrietta Papp
cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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Valéria Szijártó
dCEBINA (Central European Biotech Incubator and Accelerator) GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
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Tanja Gesell
bCalyxha Biotechnologies GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
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Gábor Nagy
dCEBINA (Central European Biotech Incubator and Accelerator) GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
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Mónika Madai
cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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Safia Zeghbib
cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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Anett Kuczmog
cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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Zsófia Lanszki
cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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Zsuzsanna Helyes
eDepartment of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Center, University of Pécs, Pécs, Hungary
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Gábor Kemenesi
cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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Ferenc Jakab
cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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Eszter Nagy
bCalyxha Biotechnologies GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
dCEBINA (Central European Biotech Incubator and Accelerator) GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
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  • For correspondence: robert.konrat@univie.ac.at eszter.nagy@cebina.eu
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Article Information

doi 
https://doi.org/10.1101/2020.09.15.296228
History 
  • September 15, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Robert Konrat, PhDa,b,*,
  2. Henrietta Papp, MSc,
  3. Valéria Szijártó, MDd,
  4. Tanja Gesell, PhDb,
  5. Gábor Nagy, MDd,
  6. Mónika Madai, MSc,
  7. Safia Zeghbibc,
  8. Anett Kuczmog, PhDc,
  9. Zsófia Lanszki, MSc,
  10. Zsuzsanna Helyes, MDe,
  11. Gábor Kemenesic,
  12. Ferenc Jakab, PhDc and
  13. Eszter Nagy, MDb,d,*
  1. aDepartment of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, A-1030 Vienna, Austria
  2. bCalyxha Biotechnologies GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
  3. cNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
  4. dCEBINA (Central European Biotech Incubator and Accelerator) GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria
  5. eDepartment of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Center, University of Pécs, Pécs, Hungary
  1. ↵*corresponding authors: Prof. Robert Konrat, Department of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, A-1030 Vienna, Austria; robert.konrat{at}univie.ac.at; tel: +4321427752202 & Eszter Nagy, CEBINA GmbH, Karl-Farkas-Gasse 22, A-1030 Vienna, Austria; eszter.nagy{at}cebina.eu; tel: +43190922082310
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The Anti-histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits SARS-CoV-2 Infection in Reconstituted Human Nasal Tissue In Vitro
Robert Konrat, Henrietta Papp, Valéria Szijártó, Tanja Gesell, Gábor Nagy, Mónika Madai, Safia Zeghbib, Anett Kuczmog, Zsófia Lanszki, Zsuzsanna Helyes, Gábor Kemenesi, Ferenc Jakab, Eszter Nagy
bioRxiv 2020.09.15.296228; doi: https://doi.org/10.1101/2020.09.15.296228
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The Anti-histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits SARS-CoV-2 Infection in Reconstituted Human Nasal Tissue In Vitro
Robert Konrat, Henrietta Papp, Valéria Szijártó, Tanja Gesell, Gábor Nagy, Mónika Madai, Safia Zeghbib, Anett Kuczmog, Zsófia Lanszki, Zsuzsanna Helyes, Gábor Kemenesi, Ferenc Jakab, Eszter Nagy
bioRxiv 2020.09.15.296228; doi: https://doi.org/10.1101/2020.09.15.296228

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