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Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets for drug repurposing
View ORCID ProfileBjoern Meyer, View ORCID ProfileJeanne Chiaravalli, View ORCID ProfilePhilip Brownridge, View ORCID ProfileDominic P. Bryne, View ORCID ProfileLeonard A. Daly, View ORCID ProfileFabrice Agou, View ORCID ProfileClaire E. Eyers, View ORCID ProfilePatrick A. Eyers, View ORCID ProfileMarco Vignuzzi, View ORCID ProfileEdward Emmott
doi: https://doi.org/10.1101/2020.09.16.297945
Bjoern Meyer
1Viral Populations and Pathogenesis Unit, CNRS, UMR 3569, Institut Pasteur, Paris, CEDEX 15, France
Jeanne Chiaravalli
2Chemogenomic and Biological Screening Core Facility, C2RT, Departments of Cell Biology & Infection and of Structural Biology Chemistry, Institut Pasteur, Paris, CEDEX 15, France
Philip Brownridge
3Centre for Proteome Research, Department of Biochemistry Systems Biology, Institute of Systems, Molecular & Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 7ZB, UK
Dominic P. Bryne
4Department of Biochemistry & Systems Biology, Institute of Systems, Molecular & Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 7ZB, UK
Leonard A. Daly
3Centre for Proteome Research, Department of Biochemistry Systems Biology, Institute of Systems, Molecular & Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 7ZB, UK
Fabrice Agou
2Chemogenomic and Biological Screening Core Facility, C2RT, Departments of Cell Biology & Infection and of Structural Biology Chemistry, Institut Pasteur, Paris, CEDEX 15, France
Claire E. Eyers
3Centre for Proteome Research, Department of Biochemistry Systems Biology, Institute of Systems, Molecular & Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 7ZB, UK
Patrick A. Eyers
4Department of Biochemistry & Systems Biology, Institute of Systems, Molecular & Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 7ZB, UK
Marco Vignuzzi
1Viral Populations and Pathogenesis Unit, CNRS, UMR 3569, Institut Pasteur, Paris, CEDEX 15, France
Edward Emmott
3Centre for Proteome Research, Department of Biochemistry Systems Biology, Institute of Systems, Molecular & Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 7ZB, UK
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Posted September 16, 2020.
Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets for drug repurposing
Bjoern Meyer, Jeanne Chiaravalli, Philip Brownridge, Dominic P. Bryne, Leonard A. Daly, Fabrice Agou, Claire E. Eyers, Patrick A. Eyers, Marco Vignuzzi, Edward Emmott
bioRxiv 2020.09.16.297945; doi: https://doi.org/10.1101/2020.09.16.297945
Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets for drug repurposing
Bjoern Meyer, Jeanne Chiaravalli, Philip Brownridge, Dominic P. Bryne, Leonard A. Daly, Fabrice Agou, Claire E. Eyers, Patrick A. Eyers, Marco Vignuzzi, Edward Emmott
bioRxiv 2020.09.16.297945; doi: https://doi.org/10.1101/2020.09.16.297945
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