Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

FGF8-mediated signaling regulates tooth developmental pace and size during odontogenesis

View ORCID ProfileChensheng Lin, Ningsheng Ruan, Linjun Li, Yibin Chen, Xiaoxiao Hu, YiPing Chen, Xuefeng Hu, View ORCID ProfileYanding Zhang
doi: https://doi.org/10.1101/2020.09.16.299388
Chensheng Lin
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, P.R. China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Chensheng Lin
Ningsheng Ruan
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, P.R. China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linjun Li
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, P.R. China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yibin Chen
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, P.R. China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaoxiao Hu
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, P.R. China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YiPing Chen
2Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xuefeng Hu
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, P.R. China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: ydzhang@fjnu.edu.cn bioxfh@fjnu.edu.cn
Yanding Zhang
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, P.R. China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yanding Zhang
  • For correspondence: ydzhang@fjnu.edu.cn bioxfh@fjnu.edu.cn
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control due to the fact that their teeth share highly conserved and well-characterized developmental processes and their developmental tempo and size vary notably. In the current study, we manipulated heterogenous recombination between human and mouse dental tissues and demonstrate that the dental mesenchyme dominates the tooth developmental tempo and size and FGF8 could be a critical player during this developmental process. Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation, prevented cell apoptosis via p38 and perhaps PI3K-Akt intracellular signaling, and impelled the transition of the cell cycle from G1- to S-phase in the tooth germ, resulting in the slowdown of the tooth developmental pace and the enlargement of the tooth size. Our results provide compelling evidence that extrinsic signals can profoundly affect tooth developmental tempo and size and the dental mesenchymal FGF8 could be a pivotal factor in controlling developmental pace and size in a non-cell-autonomous manner during mammalian odontogenesis.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • This manuscript is available as a preprint on non-commercial server bioRxiv: https://doi.org/10.1101/2020.09.16.299388.

  • Disclosure page

  • Conflicts of interest The authors declare no conflicts of interest.

  • Data Availability Statement All the data are available within the article or its supplementary materials.

  • The whole article has been revised.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted February 19, 2021.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
FGF8-mediated signaling regulates tooth developmental pace and size during odontogenesis
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
FGF8-mediated signaling regulates tooth developmental pace and size during odontogenesis
Chensheng Lin, Ningsheng Ruan, Linjun Li, Yibin Chen, Xiaoxiao Hu, YiPing Chen, Xuefeng Hu, Yanding Zhang
bioRxiv 2020.09.16.299388; doi: https://doi.org/10.1101/2020.09.16.299388
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
FGF8-mediated signaling regulates tooth developmental pace and size during odontogenesis
Chensheng Lin, Ningsheng Ruan, Linjun Li, Yibin Chen, Xiaoxiao Hu, YiPing Chen, Xuefeng Hu, Yanding Zhang
bioRxiv 2020.09.16.299388; doi: https://doi.org/10.1101/2020.09.16.299388

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Developmental Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2537)
  • Biochemistry (4983)
  • Bioengineering (3490)
  • Bioinformatics (15247)
  • Biophysics (6915)
  • Cancer Biology (5408)
  • Cell Biology (7756)
  • Clinical Trials (138)
  • Developmental Biology (4543)
  • Ecology (7169)
  • Epidemiology (2059)
  • Evolutionary Biology (10242)
  • Genetics (7522)
  • Genomics (9805)
  • Immunology (4871)
  • Microbiology (13251)
  • Molecular Biology (5153)
  • Neuroscience (29503)
  • Paleontology (203)
  • Pathology (839)
  • Pharmacology and Toxicology (1468)
  • Physiology (2146)
  • Plant Biology (4764)
  • Scientific Communication and Education (1013)
  • Synthetic Biology (1339)
  • Systems Biology (4016)
  • Zoology (770)