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Myeloid cell-associated resistance to PD-1/PD-L1 blockade in urothelial cancer revealed through bulk and single-cell RNA sequencing
Li Wang, John P. Sfakianos, Kristin G. Beaumont, Guray Akturk, Amir Horowitz, Robert Sebra, Adam M. Farkas, Sacha Gnjatic, Austin Hake, Sudeh Izadmehr, Peter Wiklund, William K Oh, Peter Szabo, Megan Wind-Rotolo, Kezi Unsal-Kacmaz, Xin Yao, Eric Schadt, Padmanee Sharma, Nina Bhardwaj, Jun Zhu, Matthew D. Galsky
doi: https://doi.org/10.1101/2020.09.16.300111
Li Wang
1Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
3Sema4, a Mount Sinai venture, Stamford, CT
John P. Sfakianos
4Department of Urology; Icahn School of Medicine at Mount Sinai, New York, NY
Kristin G. Beaumont
1Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
Guray Akturk
5Precision Immunology Institute; Icahn School of Medicine at Mount Sinai, New York, NY
Amir Horowitz
5Precision Immunology Institute; Icahn School of Medicine at Mount Sinai, New York, NY
Robert Sebra
1Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
3Sema4, a Mount Sinai venture, Stamford, CT
6Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY
Adam M. Farkas
5Precision Immunology Institute; Icahn School of Medicine at Mount Sinai, New York, NY
Sacha Gnjatic
5Precision Immunology Institute; Icahn School of Medicine at Mount Sinai, New York, NY
Austin Hake
1Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
Sudeh Izadmehr
7Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY
Peter Wiklund
4Department of Urology; Icahn School of Medicine at Mount Sinai, New York, NY
William K Oh
7Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY
Peter Szabo
8Bristol-Myers Squibb, Princeton, NJ
Megan Wind-Rotolo
8Bristol-Myers Squibb, Princeton, NJ
Kezi Unsal-Kacmaz
8Bristol-Myers Squibb, Princeton, NJ
Xin Yao
9Department of Genitourinary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
Eric Schadt
1Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
3Sema4, a Mount Sinai venture, Stamford, CT
Padmanee Sharma
10Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX
Nina Bhardwaj
5Precision Immunology Institute; Icahn School of Medicine at Mount Sinai, New York, NY
7Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY
Jun Zhu
1Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
3Sema4, a Mount Sinai venture, Stamford, CT
Matthew D. Galsky
7Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY
Article usage
Posted September 17, 2020.
Myeloid cell-associated resistance to PD-1/PD-L1 blockade in urothelial cancer revealed through bulk and single-cell RNA sequencing
Li Wang, John P. Sfakianos, Kristin G. Beaumont, Guray Akturk, Amir Horowitz, Robert Sebra, Adam M. Farkas, Sacha Gnjatic, Austin Hake, Sudeh Izadmehr, Peter Wiklund, William K Oh, Peter Szabo, Megan Wind-Rotolo, Kezi Unsal-Kacmaz, Xin Yao, Eric Schadt, Padmanee Sharma, Nina Bhardwaj, Jun Zhu, Matthew D. Galsky
bioRxiv 2020.09.16.300111; doi: https://doi.org/10.1101/2020.09.16.300111
Myeloid cell-associated resistance to PD-1/PD-L1 blockade in urothelial cancer revealed through bulk and single-cell RNA sequencing
Li Wang, John P. Sfakianos, Kristin G. Beaumont, Guray Akturk, Amir Horowitz, Robert Sebra, Adam M. Farkas, Sacha Gnjatic, Austin Hake, Sudeh Izadmehr, Peter Wiklund, William K Oh, Peter Szabo, Megan Wind-Rotolo, Kezi Unsal-Kacmaz, Xin Yao, Eric Schadt, Padmanee Sharma, Nina Bhardwaj, Jun Zhu, Matthew D. Galsky
bioRxiv 2020.09.16.300111; doi: https://doi.org/10.1101/2020.09.16.300111
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