New Results
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
View ORCID ProfileTimothy N. Hoang, Maria Pino, Arun K. Boddapati, Elise G. Viox, Carly E. Starke, Amit A. Upadhyay, Sanjeev Gumber, Kathleen Busman-Sahay, Zachary Strongin, Justin L. Harper, Gregory K. Tharp, Kathryn L. Pellegrini, Shannon Kirejczyk, Keivan Zandi, Sijia Tao, Tristan R. Horton, Elizabeth N. Beagle, Ernestine A. Mahar, Michelle YH Lee, Joyce Cohen, Sherrie M. Jean, Jennifer S. Wood, Fawn Connor-Stroud, Rachelle L. Stammen, Olivia M. Delmas, Shelly Wang, Kimberly A. Cooney, Michael N. Sayegh, Lanfang Wang, Daniela Weiskopf, Peter D. Filev, Jesse Waggoner, Anne Piantadosi, Sudhir P. Kasturi, Hilmi Al- Shakhshir, Susan P. Ribeiro, Rafick P. Sekaly, Rebecca D. Levit, Jacob D. Estes, Thomas H. Vanderford, Raymond F. Schinazi, Steven E. Bosinger, Mirko Paiardini
doi: https://doi.org/10.1101/2020.09.16.300277
Timothy N. Hoang
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Maria Pino
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Arun K. Boddapati
2Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Elise G. Viox
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Carly E. Starke
9Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA
Amit A. Upadhyay
2Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Sanjeev Gumber
6Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
7Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Kathleen Busman-Sahay
9Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA
Zachary Strongin
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Justin L. Harper
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Gregory K. Tharp
2Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Kathryn L. Pellegrini
2Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Shannon Kirejczyk
7Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Keivan Zandi
8Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA
Sijia Tao
8Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA
Tristan R. Horton
2Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Elizabeth N. Beagle
2Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Ernestine A. Mahar
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Michelle YH Lee
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Joyce Cohen
3Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Sherrie M. Jean
3Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Jennifer S. Wood
3Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Fawn Connor-Stroud
3Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Rachelle L. Stammen
3Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Olivia M. Delmas
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Shelly Wang
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Kimberly A. Cooney
4Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Michael N. Sayegh
4Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Lanfang Wang
4Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Daniela Weiskopf
12Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA
Peter D. Filev
5Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia, USA
Jesse Waggoner
4Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Anne Piantadosi
4Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
6Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Sudhir P. Kasturi
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Hilmi Al- Shakhshir
11Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Susan P. Ribeiro
11Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Rafick P. Sekaly
11Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Rebecca D. Levit
4Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Jacob D. Estes
9Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA
10Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA
Thomas H. Vanderford
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Raymond F. Schinazi
8Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA
Steven E. Bosinger
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
2Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
6Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Mirko Paiardini
1Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
6Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA
Posted September 16, 2020.
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
Timothy N. Hoang, Maria Pino, Arun K. Boddapati, Elise G. Viox, Carly E. Starke, Amit A. Upadhyay, Sanjeev Gumber, Kathleen Busman-Sahay, Zachary Strongin, Justin L. Harper, Gregory K. Tharp, Kathryn L. Pellegrini, Shannon Kirejczyk, Keivan Zandi, Sijia Tao, Tristan R. Horton, Elizabeth N. Beagle, Ernestine A. Mahar, Michelle YH Lee, Joyce Cohen, Sherrie M. Jean, Jennifer S. Wood, Fawn Connor-Stroud, Rachelle L. Stammen, Olivia M. Delmas, Shelly Wang, Kimberly A. Cooney, Michael N. Sayegh, Lanfang Wang, Daniela Weiskopf, Peter D. Filev, Jesse Waggoner, Anne Piantadosi, Sudhir P. Kasturi, Hilmi Al- Shakhshir, Susan P. Ribeiro, Rafick P. Sekaly, Rebecca D. Levit, Jacob D. Estes, Thomas H. Vanderford, Raymond F. Schinazi, Steven E. Bosinger, Mirko Paiardini
bioRxiv 2020.09.16.300277; doi: https://doi.org/10.1101/2020.09.16.300277
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
Timothy N. Hoang, Maria Pino, Arun K. Boddapati, Elise G. Viox, Carly E. Starke, Amit A. Upadhyay, Sanjeev Gumber, Kathleen Busman-Sahay, Zachary Strongin, Justin L. Harper, Gregory K. Tharp, Kathryn L. Pellegrini, Shannon Kirejczyk, Keivan Zandi, Sijia Tao, Tristan R. Horton, Elizabeth N. Beagle, Ernestine A. Mahar, Michelle YH Lee, Joyce Cohen, Sherrie M. Jean, Jennifer S. Wood, Fawn Connor-Stroud, Rachelle L. Stammen, Olivia M. Delmas, Shelly Wang, Kimberly A. Cooney, Michael N. Sayegh, Lanfang Wang, Daniela Weiskopf, Peter D. Filev, Jesse Waggoner, Anne Piantadosi, Sudhir P. Kasturi, Hilmi Al- Shakhshir, Susan P. Ribeiro, Rafick P. Sekaly, Rebecca D. Levit, Jacob D. Estes, Thomas H. Vanderford, Raymond F. Schinazi, Steven E. Bosinger, Mirko Paiardini
bioRxiv 2020.09.16.300277; doi: https://doi.org/10.1101/2020.09.16.300277
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