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Alterations to the cardiac metabolome induced by chronic T. cruzi infection relate to the degree of cardiac pathology

Kristyn Hoffman, Zongyuan Liu, Ekram Hossain, Maria Elena Bottazzi, Peter Hotez, Kathryn Jones, Laura-Isobel McCall
doi: https://doi.org/10.1101/2020.09.17.300608
Kristyn Hoffman
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States of America
2Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States of America
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Zongyuan Liu
3Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America
4Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, Oklahoma, United States of America
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Ekram Hossain
3Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America
4Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, Oklahoma, United States of America
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Maria Elena Bottazzi
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States of America
2Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States of America
5Texas Children’s Hospital Center for Vaccine Development, Houston, TX
6Department of Biology, Baylor University, Waco, TX, United States of America
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Peter Hotez
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States of America
2Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States of America
5Texas Children’s Hospital Center for Vaccine Development, Houston, TX
6Department of Biology, Baylor University, Waco, TX, United States of America
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Kathryn Jones
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States of America
2Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States of America
5Texas Children’s Hospital Center for Vaccine Development, Houston, TX
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  • For correspondence: lmccall@ou.edu kathrynj@bcm.edu
Laura-Isobel McCall
3Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America
4Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, Oklahoma, United States of America
7Department of Microbiology and Plant Biology, University of Oklahoma, Norman, Oklahoma, United States of America
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  • For correspondence: lmccall@ou.edu kathrynj@bcm.edu
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Abstract

Chronic Chagasic cardiomyopathy (CCC) is a Neglected Tropical Disease caused by the parasite Trypanosoma cruzi. The pathognomonic findings in symptomatic CCC patients and animal models includes diffuse cardiac fibrosis and persistent inflammation with persistent parasite presence in the heart. This study investigated chemical alterations in different regions of the heart in relation to cardiac pathology indicators to better understand the long-term pathogenesis of this neglected disease. We used data from echocardiography, fibrosis biomarkers, and histopathological analysis to fully evaluate cardiac pathology. Metabolites isolated from the pericardial and endocardial sides of the right ventricular myocardium were analyzed by liquid chromatography tandem mass spectrometry. The endocardial sections contained significantly less cardiac inflammation and fibrosis than the pericardial sections. Cardiac levels of acylcarnitines, phosphocholines, and other metabolites were significantly disrupted in accordance with cardiac fibrosis, inflammation, and serum fibrosis biomarker levels. These findings have potential implications in treatment and monitoring for CCC patients.

Competing Interest Statement

The authors have declared no competing interest.

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Posted September 17, 2020.
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Alterations to the cardiac metabolome induced by chronic T. cruzi infection relate to the degree of cardiac pathology
Kristyn Hoffman, Zongyuan Liu, Ekram Hossain, Maria Elena Bottazzi, Peter Hotez, Kathryn Jones, Laura-Isobel McCall
bioRxiv 2020.09.17.300608; doi: https://doi.org/10.1101/2020.09.17.300608
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Alterations to the cardiac metabolome induced by chronic T. cruzi infection relate to the degree of cardiac pathology
Kristyn Hoffman, Zongyuan Liu, Ekram Hossain, Maria Elena Bottazzi, Peter Hotez, Kathryn Jones, Laura-Isobel McCall
bioRxiv 2020.09.17.300608; doi: https://doi.org/10.1101/2020.09.17.300608

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