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The Dual Mechanisms of Cognitive Control (DMCC) Project

View ORCID ProfileTodd S. Braver, Alexander Kizhner, View ORCID ProfileRongxiang Tang, Michael C. Freund, View ORCID ProfileJoset A. Etzel
doi: https://doi.org/10.1101/2020.09.18.304402
Todd S. Braver
1Department of Psychological and Brain Sciences, Washington University in St. Louis
2Departments of Radiology, Washington University in St. Louis
3Departments of Neuroscience, Washington University in St. Louis
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  • For correspondence: tbraver@wustl.edu
Alexander Kizhner
1Department of Psychological and Brain Sciences, Washington University in St. Louis
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Rongxiang Tang
1Department of Psychological and Brain Sciences, Washington University in St. Louis
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Michael C. Freund
1Department of Psychological and Brain Sciences, Washington University in St. Louis
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Joset A. Etzel
1Department of Psychological and Brain Sciences, Washington University in St. Louis
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Abstract

The Dual Mechanisms of Cognitive Control (DMCC) project provides an ambitious and rigorous empirical test of a theoretical framework that posits two key cognitive control modes: proactive and reactive. The framework’s central tenets are that proactive and reactive control reflect domain-general dimensions of individual variation, with distinctive neural signatures, involving lateral prefrontal cortex (PFC) in interactions with other brain networks and circuits (e.g., frontoparietal, cingulo-opercular). In the DMCC project, each participant is scanned while performing theoretically-targeted variants of multiple well-established cognitive control tasks (Stroop, Cued Task-Switching, AX-CPT, Sternberg Working Memory) in three separate imaging sessions, that each encourage utilization of different control modes, plus also completes an extensive out-of-scanner individual differences battery. Additional key features of the project include a high spatio-temporal resolution (multiband) acquisition protocol, and a sample that includes a substantial subset of monozygotic twin pairs and participants recruited from the Human Connectome Project. Although data collection is still continuing (target N=200), we provide an overview of the study design and protocol, planned analytic approaches and methodological development, along with initial results (N=80) revealing novel evidence of a domain-general neural signature of reactive control. In the interests of scientific community building, the dataset will be made public at project completion, so it can serve as a valuable resource.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://osf.io/xvzrf/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 20, 2020.
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The Dual Mechanisms of Cognitive Control (DMCC) Project
Todd S. Braver, Alexander Kizhner, Rongxiang Tang, Michael C. Freund, Joset A. Etzel
bioRxiv 2020.09.18.304402; doi: https://doi.org/10.1101/2020.09.18.304402
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The Dual Mechanisms of Cognitive Control (DMCC) Project
Todd S. Braver, Alexander Kizhner, Rongxiang Tang, Michael C. Freund, Joset A. Etzel
bioRxiv 2020.09.18.304402; doi: https://doi.org/10.1101/2020.09.18.304402

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