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Rapid and efficient inactivation of surface dried SARS-CoV-2 by UV-C irradiation

Natalia Ruetalo, Ramona Businger, View ORCID ProfileMichael Schindler
doi: https://doi.org/10.1101/2020.09.22.308098
Natalia Ruetalo
1Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
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Ramona Businger
1Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
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Michael Schindler
1Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
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  • ORCID record for Michael Schindler
  • For correspondence: michael.schindler@med.uni-tuebingen.de
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Abstract

The SARS-CoV-2 pandemic urges for cheap, reliable and rapid technologies for disinfection and decontamination. We here evaluated the efficiency of UV-C irradiation to inactivate surface dried SARS-CoV-2. Drying for two hours did not have a major impact on the infectivity of SARS-CoV-2, indicating that exhaled virus in droplets or aerosols stays infectious on surfaces at least for a certain amount of time. Strikingly, short exposure of high titer surface dried virus (3*10^6 IU/ml) with UV-C light (16 mJ/cm2) resulted in a total reduction of SARS-CoV-2 infectivity. Together, our results demonstrate that SARS-CoV-2 is rapidly inactivated by relatively low doses of UV-C irradiation. Hence, UV-C treatment is an effective non-chemical possibility to decontaminate surfaces from high-titer infectious SARS-CoV-2.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • We recalculated the UV-C dose of the moving regime and updated the manuscript accordingly.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted October 07, 2020.
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Rapid and efficient inactivation of surface dried SARS-CoV-2 by UV-C irradiation
Natalia Ruetalo, Ramona Businger, Michael Schindler
bioRxiv 2020.09.22.308098; doi: https://doi.org/10.1101/2020.09.22.308098
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Rapid and efficient inactivation of surface dried SARS-CoV-2 by UV-C irradiation
Natalia Ruetalo, Ramona Businger, Michael Schindler
bioRxiv 2020.09.22.308098; doi: https://doi.org/10.1101/2020.09.22.308098

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