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Breast tumors escape endocrine therapy by ER-independent mechanisms triggered by the coordinated activities of HER2/HER3 and deacetylated FOXA1
Siv Gilfillan, Shixiong Wang, Madhumohan R. Katika, Jens Henrik Norum, Helga Bergholtz, Elisa Fiorito, Siri Nordhagen, Yogita Sharma, Sachin Singh, Venkata S. Somisety, Anne-Marthe Fosdahl, Silje Nord, Olav Engebraaten, Ole Christian Lingjaerde, Anne-Lise Børresen-Dale, Kristine Kleivi Sahlberg, Therese Sørlie, Meritxell Bellet, Sandra Lopez-Aviles, Antoni Hurtado
doi: https://doi.org/10.1101/2020.09.22.308569
Siv Gilfillan
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Shixiong Wang
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Madhumohan R. Katika
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
Jens Henrik Norum
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
Helga Bergholtz
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
Elisa Fiorito
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Siri Nordhagen
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Yogita Sharma
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Sachin Singh
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Venkata S. Somisety
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Anne-Marthe Fosdahl
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
Silje Nord
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
Olav Engebraaten
3Department of Oncology, Oslo University Hospital, and Department of Tumor Biology, Institute for Cancer Research, University of Oslo, N-0310 Oslo, Norway
Ole Christian Lingjaerde
4Department of Informatics, Faculty of Mathematics and Natural Sciences, University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
5K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway
Anne-Lise Børresen-Dale
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
5K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway
Kristine Kleivi Sahlberg
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
Therese Sørlie
2Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
Meritxell Bellet
6Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Medical Oncology Department, Barcelona, Spain
Sandra Lopez-Aviles
1Cell cycle regulation group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, P.O. 1137 Blindern, 0318, Oslo, Norway
Antoni Hurtado
7Cancer genomics and proteomics group. Department of Biomedical Sciences. University of Barcelona, Casanova, 143, 08014 Barcelona
Posted September 23, 2020.
Breast tumors escape endocrine therapy by ER-independent mechanisms triggered by the coordinated activities of HER2/HER3 and deacetylated FOXA1
Siv Gilfillan, Shixiong Wang, Madhumohan R. Katika, Jens Henrik Norum, Helga Bergholtz, Elisa Fiorito, Siri Nordhagen, Yogita Sharma, Sachin Singh, Venkata S. Somisety, Anne-Marthe Fosdahl, Silje Nord, Olav Engebraaten, Ole Christian Lingjaerde, Anne-Lise Børresen-Dale, Kristine Kleivi Sahlberg, Therese Sørlie, Meritxell Bellet, Sandra Lopez-Aviles, Antoni Hurtado
bioRxiv 2020.09.22.308569; doi: https://doi.org/10.1101/2020.09.22.308569
Breast tumors escape endocrine therapy by ER-independent mechanisms triggered by the coordinated activities of HER2/HER3 and deacetylated FOXA1
Siv Gilfillan, Shixiong Wang, Madhumohan R. Katika, Jens Henrik Norum, Helga Bergholtz, Elisa Fiorito, Siri Nordhagen, Yogita Sharma, Sachin Singh, Venkata S. Somisety, Anne-Marthe Fosdahl, Silje Nord, Olav Engebraaten, Ole Christian Lingjaerde, Anne-Lise Børresen-Dale, Kristine Kleivi Sahlberg, Therese Sørlie, Meritxell Bellet, Sandra Lopez-Aviles, Antoni Hurtado
bioRxiv 2020.09.22.308569; doi: https://doi.org/10.1101/2020.09.22.308569
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