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Effects of a 50-Hz electric field on sleep quality and life span mediated by ultraviolet (UV)-A/blue light photoreceptor CRYPTOCHROME in Drosophila melanogaster

View ORCID ProfileHaruhisa Kawasaki, Hideyuki Okano, Takaki Nedachi, Yuzo Nakagawa-Yagi, Akikuni Hara, Norio Ishida
doi: https://doi.org/10.1101/2020.09.23.310862
Haruhisa Kawasaki
1Institute for Chronobiology, Foundation for Advancement of International Science (FAIS), 3-24-16 Kasuga, Tsukuba, Ibaraki, 305-0821, Japan
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  • ORCID record for Haruhisa Kawasaki
Hideyuki Okano
2Hakuju Institute for Health Science Co., Ltd., 37-5 Tomigaya 1-chome, Shibuya-ku, Tokyo 151-0063, Japan
3Graduate School of Science and Engineering, Saitama University
4Soken Medical Co., Ltd., 1-36-20 Takada Toshima-ku, Tokyo, 171-0033, Japan
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Takaki Nedachi
2Hakuju Institute for Health Science Co., Ltd., 37-5 Tomigaya 1-chome, Shibuya-ku, Tokyo 151-0063, Japan
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Yuzo Nakagawa-Yagi
2Hakuju Institute for Health Science Co., Ltd., 37-5 Tomigaya 1-chome, Shibuya-ku, Tokyo 151-0063, Japan
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Akikuni Hara
2Hakuju Institute for Health Science Co., Ltd., 37-5 Tomigaya 1-chome, Shibuya-ku, Tokyo 151-0063, Japan
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Norio Ishida
1Institute for Chronobiology, Foundation for Advancement of International Science (FAIS), 3-24-16 Kasuga, Tsukuba, Ibaraki, 305-0821, Japan
5Tsukuba Innovation Arena, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan
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  • For correspondence: ishida@fais.or.jp
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Abstract

Although electric fields (EF) exert beneficial effects on animal wound healing and differentiation, the molecular mechanisms of these effects have remained unclear for years. Therefore, we aimed to elucidate the molecular mechanisms underlying these effects in Drosophila melanogaster as a genetic animal model. The sleep quality of wild-type (WT) flies was improved by exposure to a 50-Hz (35 kv/m) constant electric field during the daytime, but not during the night. This effect was undetectable in Cryptochrome mutant (Cryb) flies. Exposure to a 50-Hz electric field under low nutrient conditions elongated the lifespan of male and female WT flies by ~18%, but not of three diferrent Cry mutants and Cry RNAi strains. Metabolome analysis indicated that the adenosine triphosphate (ATP) content was 5-fold higher in intact WT than Cry gene mutant strains exposed to an electric field.

A putative magnetoreceptor protein and UV-A/blue light photoreceptor, CRYPTOCHROME (CRY) is involved in electric field receptors in animals. The present findings constitute hitherto unknown genetic evidence of a CRY-based system that is electric-field sensitive in animals.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted September 25, 2020.
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Effects of a 50-Hz electric field on sleep quality and life span mediated by ultraviolet (UV)-A/blue light photoreceptor CRYPTOCHROME in Drosophila melanogaster
Haruhisa Kawasaki, Hideyuki Okano, Takaki Nedachi, Yuzo Nakagawa-Yagi, Akikuni Hara, Norio Ishida
bioRxiv 2020.09.23.310862; doi: https://doi.org/10.1101/2020.09.23.310862
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Effects of a 50-Hz electric field on sleep quality and life span mediated by ultraviolet (UV)-A/blue light photoreceptor CRYPTOCHROME in Drosophila melanogaster
Haruhisa Kawasaki, Hideyuki Okano, Takaki Nedachi, Yuzo Nakagawa-Yagi, Akikuni Hara, Norio Ishida
bioRxiv 2020.09.23.310862; doi: https://doi.org/10.1101/2020.09.23.310862

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