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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
Douglas C. Palmer, Beau R. Webber, Yogin Patel, Matthew J. Johnson, Christine M. Kariya, Walker S. Lahr, Maria R. Parkhurst, Jared J Gartner, Todd D Prickett, Frank J. Lowery, Rigel J. Kishton, Devikala Gurusamy, Zulmarie Franco, Suman K. Vodnala, Miechaleen D. Diers, Natalie K. Wolf, Nicholas J. Slipek, David H. McKenna, Darin Sumstad, Lydia Viney, Tom Henley, Tilmann Bürckstümmer, Oliver Baker, Ying Hu, Chunhua Yan, Daoud Meerzaman, Kartik Padhan, Winnie Lo, Parisa Malekzadeh, Li Jia, Drew C. Deniger, Shashank J. Patel, Paul F. Robbins, R. Scott McIvor, Modassir Choudhry, Steven A. Rosenberg, Branden S. Moriarity, Nicholas P. Restifo
doi: https://doi.org/10.1101/2020.09.24.306571
Douglas C. Palmer
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Beau R. Webber
2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
4Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA
Yogin Patel
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Matthew J. Johnson
2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
4Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA
Christine M. Kariya
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Walker S. Lahr
2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
4Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA
Maria R. Parkhurst
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Jared J Gartner
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Todd D Prickett
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Frank J. Lowery
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Rigel J. Kishton
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Devikala Gurusamy
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Zulmarie Franco
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Suman K. Vodnala
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Miechaleen D. Diers
2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
4Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA
Natalie K. Wolf
2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
4Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA
Nicholas J. Slipek
2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
4Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA
David H. McKenna
5Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Darin Sumstad
6Molecular and Cellular Therapeutics, University of Minnesota, Saint Paul, Minnesota, USA
Lydia Viney
7Intima Bioscience, Inc. New York, NY, USA
Tom Henley
7Intima Bioscience, Inc. New York, NY, USA
Tilmann Bürckstümmer
7Intima Bioscience, Inc. New York, NY, USA
Oliver Baker
7Intima Bioscience, Inc. New York, NY, USA
Ying Hu
8The Center for Biomedical Informatics and Information Technology (CBIIT), National Institutes of Health, Bethesda, Maryland, USA
Chunhua Yan
8The Center for Biomedical Informatics and Information Technology (CBIIT), National Institutes of Health, Bethesda, Maryland, USA
Daoud Meerzaman
8The Center for Biomedical Informatics and Information Technology (CBIIT), National Institutes of Health, Bethesda, Maryland, USA
Kartik Padhan
9National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health, Bethesda, Maryland, USA
Winnie Lo
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Parisa Malekzadeh
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Li Jia
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Drew C. Deniger
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Shashank J. Patel
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Paul F. Robbins
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
R. Scott McIvor
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
10Department of Genetics, Cell Biology and Development, University of Minnesota, MN, USA
Modassir Choudhry
7Intima Bioscience, Inc. New York, NY, USA
Steven A. Rosenberg
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Branden S. Moriarity
2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
4Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA
Nicholas P. Restifo
1Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA
Article usage
Posted September 25, 2020.
Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
Douglas C. Palmer, Beau R. Webber, Yogin Patel, Matthew J. Johnson, Christine M. Kariya, Walker S. Lahr, Maria R. Parkhurst, Jared J Gartner, Todd D Prickett, Frank J. Lowery, Rigel J. Kishton, Devikala Gurusamy, Zulmarie Franco, Suman K. Vodnala, Miechaleen D. Diers, Natalie K. Wolf, Nicholas J. Slipek, David H. McKenna, Darin Sumstad, Lydia Viney, Tom Henley, Tilmann Bürckstümmer, Oliver Baker, Ying Hu, Chunhua Yan, Daoud Meerzaman, Kartik Padhan, Winnie Lo, Parisa Malekzadeh, Li Jia, Drew C. Deniger, Shashank J. Patel, Paul F. Robbins, R. Scott McIvor, Modassir Choudhry, Steven A. Rosenberg, Branden S. Moriarity, Nicholas P. Restifo
bioRxiv 2020.09.24.306571; doi: https://doi.org/10.1101/2020.09.24.306571
Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
Douglas C. Palmer, Beau R. Webber, Yogin Patel, Matthew J. Johnson, Christine M. Kariya, Walker S. Lahr, Maria R. Parkhurst, Jared J Gartner, Todd D Prickett, Frank J. Lowery, Rigel J. Kishton, Devikala Gurusamy, Zulmarie Franco, Suman K. Vodnala, Miechaleen D. Diers, Natalie K. Wolf, Nicholas J. Slipek, David H. McKenna, Darin Sumstad, Lydia Viney, Tom Henley, Tilmann Bürckstümmer, Oliver Baker, Ying Hu, Chunhua Yan, Daoud Meerzaman, Kartik Padhan, Winnie Lo, Parisa Malekzadeh, Li Jia, Drew C. Deniger, Shashank J. Patel, Paul F. Robbins, R. Scott McIvor, Modassir Choudhry, Steven A. Rosenberg, Branden S. Moriarity, Nicholas P. Restifo
bioRxiv 2020.09.24.306571; doi: https://doi.org/10.1101/2020.09.24.306571
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