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Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease

Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
doi: https://doi.org/10.1101/2020.09.24.308122
Abhinav Sharma
1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf
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  • For correspondence: esther.florin@hhu.de
Diego Vidaurre
2Department of Psychiatry, University of Oxford, Oxford, UK
3Department of Clinical Health, Aarhus University, Aarhus, Denmark
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Jan Vesper
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Alfons Schnitzler
1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf
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Esther Florin
1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf
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  • For correspondence: esther.florin@hhu.de
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Abstract

Pathological oscillations are a hallmark of neural activity in Parkinson’s disease (PD). Time-averaged analyses are usually employed to study changes in spectral connectivity with and without dopaminergic intervention in PD. This prevents differentiating the pathological vs physiological nature of dynamically evolving oscillatory activity serving multiple functional roles. Using a Hidden Markov Model on combined STN-LFP and whole-brain MEG data from 17 PD patients we discovered three distinct network activity patterns. One network was related to adverse effects of increased dopamine, a second one maintained ON-medication spatio-spectrally selective cortico-STN connectivity and finally, a local STN-STN network emerged which indicated the inability of L-DOPA to modify local basal ganglia activity. Temporally we found that, ON medication, the cortico-STN and the STN-STN network increased in duration whereas the cortico-cortical network occurred less frequently. Our results provide a spectrally diverse and spatially specific understanding of transient network connectivity in PD on a whole brain level, disambiguating temporal and spatial changes of the underlying networks. By providing electrophysiological evidence for the differential effects of L-DOPA intervention in PD, our findings open further avenues for electrical and pharmacological intervention in PD.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted September 24, 2020.
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Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease
Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
bioRxiv 2020.09.24.308122; doi: https://doi.org/10.1101/2020.09.24.308122
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Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease
Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
bioRxiv 2020.09.24.308122; doi: https://doi.org/10.1101/2020.09.24.308122

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