Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease

Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
doi: https://doi.org/10.1101/2020.09.24.308122
Abhinav Sharma
1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Esther.Florin@hhu.de Abhinav.Sharma@med.uni-duesseldorf.de
Diego Vidaurre
2Department of Psychiatry, University of Oxford, Oxford, UK
3Department of Clinical Health, Aarhus University, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan Vesper
4Department of Neurosurgery, University Hospital Düsseldorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alfons Schnitzler
1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
5Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Esther Florin
1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Esther.Florin@hhu.de Abhinav.Sharma@med.uni-duesseldorf.de
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Pathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson’s disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to communication within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with deteriorated frontal executive functioning as a side effect of dopamine treatment in Parkinson’s disease. In addition, dopamine caused the beta band activity to switch from an STN-mediated motor network to a frontoparietal-mediated one. In contrast, dopamine did not modify locally-originating STN oscillations in PD. STN–STN synchrony emerged both on and off medication. By providing electrophysiological evidence for the differential effects of dopaminergic medication on the discovered networks, our findings open further avenues for electrical and pharmacological interventions in PD.

Competing Interest Statement

AS has been serving as a consultant for Medtronic Inc, Boston Scientific, St. Jude Medical, Gruenenthal, and has received lecture fees from Abbvie, Boston Scientific, St. Jude Medical, Medtronic Inc, UCB

  • List of abbreviations
    comms
    Communication state
    DBS
    Deep brain stimulation
    EEG
    Electroencephalography
    ECG
    Electrocardiography
    EOG
    Electrooculography
    FO
    Fractional occupancy
    GMM
    Gaussian mixture model
    HMM
    Hidden Markov model
    hyper
    DA Hyper-dopaminergic state
    intraMED
    intra-medication
    interMED
    inter-medication
    L-DOPA
    Levodopa
    LFP
    Local field potential
    MEG
    Magnetoencephalography
    NNMF
    Non-negative matrix factorization
    PD
    Parkinson’s disease
    PFC
    Prefrontal cortex
    PCA
    Principal component analysis
    STN
    Subthalamic nucleus
    TDE
    Time-delay embedding
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
    Back to top
    PreviousNext
    Posted January 13, 2021.
    Download PDF
    Email

    Thank you for your interest in spreading the word about bioRxiv.

    NOTE: Your email address is requested solely to identify you as the sender of this article.

    Enter multiple addresses on separate lines or separate them with commas.
    Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease
    (Your Name) has forwarded a page to you from bioRxiv
    (Your Name) thought you would like to see this page from the bioRxiv website.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Share
    Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease
    Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
    bioRxiv 2020.09.24.308122; doi: https://doi.org/10.1101/2020.09.24.308122
    Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    Citation Tools
    Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease
    Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
    bioRxiv 2020.09.24.308122; doi: https://doi.org/10.1101/2020.09.24.308122

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Subject Area

    • Neuroscience
    Subject Areas
    All Articles
    • Animal Behavior and Cognition (2409)
    • Biochemistry (4757)
    • Bioengineering (3300)
    • Bioinformatics (14584)
    • Biophysics (6591)
    • Cancer Biology (5132)
    • Cell Biology (7384)
    • Clinical Trials (138)
    • Developmental Biology (4327)
    • Ecology (6826)
    • Epidemiology (2057)
    • Evolutionary Biology (9843)
    • Genetics (7309)
    • Genomics (9471)
    • Immunology (4509)
    • Microbiology (12597)
    • Molecular Biology (4904)
    • Neuroscience (28113)
    • Paleontology (198)
    • Pathology (799)
    • Pharmacology and Toxicology (1372)
    • Physiology (1996)
    • Plant Biology (4452)
    • Scientific Communication and Education (970)
    • Synthetic Biology (1293)
    • Systems Biology (3894)
    • Zoology (718)