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Plasticity of the primary metabolome in 241 cold grown Arabidopsis thaliana accessions and its relation to natural habitat temperature

View ORCID ProfileJakob Weiszmann, View ORCID ProfilePieter Clauw, Joanna Jagoda, Ilka Reichardt-Gomez, Stefanie Koemeda, Jakub Jez, View ORCID ProfileMagnus Nordborg, View ORCID ProfileDirk Walther, View ORCID ProfileThomas Nägele, View ORCID ProfileWolfram Weckwerth
doi: https://doi.org/10.1101/2020.09.24.311092
Jakob Weiszmann
1Molecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
2Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria
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  • ORCID record for Jakob Weiszmann
Pieter Clauw
3Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna, Austria
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Joanna Jagoda
3Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna, Austria
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Ilka Reichardt-Gomez
3Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna, Austria
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Stefanie Koemeda
4Plant Sciences Facility, Vienna BioCenter Core Facilities GmbH (VBCF), Vienna, Austria
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Jakub Jez
4Plant Sciences Facility, Vienna BioCenter Core Facilities GmbH (VBCF), Vienna, Austria
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Magnus Nordborg
3Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna, Austria
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Dirk Walther
5Max-Planck-Institute of Molecular Plant Physiology, Potsdam, Germany
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Thomas Nägele
6Plant Evolutionary Cell Biology, LMU Munich, Munich, Germany
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  • ORCID record for Thomas Nägele
  • For correspondence: thomas.naegele@lmu.de wolfram.weckwerth@univie.ac.at
Wolfram Weckwerth
1Molecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
2Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria
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  • For correspondence: thomas.naegele@lmu.de wolfram.weckwerth@univie.ac.at
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Abstract

In the present study, 241 natural accessions of Arabidopsis thaliana were grown under two different temperature regimes, 16 °C and 6 °C, and growth parameters were recorded together with metabolite profiles to investigate the natural variation in metabolic responses and growth rates. Primary metabolism and growth rates of accessions significantly differed between accessions and both growth conditions. Relative growth rates showed high correlations to specific metabolite pools. Metabolic distances based on whole metabolite profiles were built from principal component centroids between both growth setups. Genomic prediction using ridge-regression best linear unbiased prediction (rrBLUP) revealed a significant prediction accuracy of metabolite profiles in both conditions and metabolic distances, which suggests a tight relationship between genome and primary metabolome. GWAS analysis revealed significantly associated SNPs for a number of metabolites, especially for fumarate metabolism at low temperature. A highly significant correlation was observed between metabolic distances and maximum temperature in the original growth habitat between January and March. Inverse data-driven modelling revealed that metabolic pathway regulation and metabolic reaction elasticities distinguish accessions originating from warm and cold growth habitats.

Competing Interest Statement

The authors have declared no competing interest.

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Posted September 25, 2020.
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Plasticity of the primary metabolome in 241 cold grown Arabidopsis thaliana accessions and its relation to natural habitat temperature
Jakob Weiszmann, Pieter Clauw, Joanna Jagoda, Ilka Reichardt-Gomez, Stefanie Koemeda, Jakub Jez, Magnus Nordborg, Dirk Walther, Thomas Nägele, Wolfram Weckwerth
bioRxiv 2020.09.24.311092; doi: https://doi.org/10.1101/2020.09.24.311092
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Plasticity of the primary metabolome in 241 cold grown Arabidopsis thaliana accessions and its relation to natural habitat temperature
Jakob Weiszmann, Pieter Clauw, Joanna Jagoda, Ilka Reichardt-Gomez, Stefanie Koemeda, Jakub Jez, Magnus Nordborg, Dirk Walther, Thomas Nägele, Wolfram Weckwerth
bioRxiv 2020.09.24.311092; doi: https://doi.org/10.1101/2020.09.24.311092

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