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Distinct recruitment of feed-forward and recurrent pathways across higher-order areas of mouse visual cortex

View ORCID ProfileJennifer Y. Li, Charles A. Hass, Ian Matthews, Amy C. Kristl, View ORCID ProfileLindsey L. Glickfeld
doi: https://doi.org/10.1101/2020.09.24.312140
Jennifer Y. Li
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Charles A. Hass
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Ian Matthews
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Amy C. Kristl
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Lindsey L. Glickfeld
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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  • ORCID record for Lindsey L. Glickfeld
  • For correspondence: glickfeld@neuro.duke.edu
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Abstract

Cortical visual processing transforms features of the external world into increasingly complex and specialized neuronal representations. These transformations arise in part through target-specific routing of information; however, within-area computations may also contribute to area-specific function. Here, we sought to determine whether higher-order visual cortical areas LM, AL, PM, and AM have specialized anatomical and physiological properties by using a combination of whole-cell recordings and optogenetic stimulation of V1 axons in vitro. We discovered area-specific differences in the strength of recruitment of interneurons through feed-forward and recurrent pathways, as well as differences in cell-intrinsic properties and interneuron densities. These differences were most striking when comparing across medial and lateral areas, suggesting that these areas have distinct profiles for net excitability and integration of V1 inputs. Thus, cortical areas are not defined simply by the information they receive, but also by area-specific circuit properties that enable specialized filtering of these inputs.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 25, 2020.
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Distinct recruitment of feed-forward and recurrent pathways across higher-order areas of mouse visual cortex
Jennifer Y. Li, Charles A. Hass, Ian Matthews, Amy C. Kristl, Lindsey L. Glickfeld
bioRxiv 2020.09.24.312140; doi: https://doi.org/10.1101/2020.09.24.312140
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Distinct recruitment of feed-forward and recurrent pathways across higher-order areas of mouse visual cortex
Jennifer Y. Li, Charles A. Hass, Ian Matthews, Amy C. Kristl, Lindsey L. Glickfeld
bioRxiv 2020.09.24.312140; doi: https://doi.org/10.1101/2020.09.24.312140

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