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Prophylactic intranasal administration of a TLR2 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

Pamela C. Proud, Daphne Tsitoura, Robert J. Watson, Brendon Y Chua, Marilyn J. Aram, Kevin R. Bewley, Breeze E. Cavell, Rebecca Cobb, Stuart Dowall, Susan A. Fotheringham, Catherine M. K. Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A. Ryan, Gillian S. Slack, Stephen Thomas, Nadina I. Wand, Paul Yeates, Christophe Demaison, David C. Jackson, Nathan W. Bartlett, Francesca Mercuri, Miles W. Carroll
doi: https://doi.org/10.1101/2020.09.25.309914
Pamela C. Proud
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Daphne Tsitoura
2Ena Respiratory, Level 9, 31 Queen St, Melbourne, Victoria, 3000, Australia
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Robert J. Watson
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Brendon Y Chua
3Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria 3000, Australia
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Marilyn J. Aram
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Kevin R. Bewley
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Breeze E. Cavell
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Rebecca Cobb
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Stuart Dowall
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Susan A. Fotheringham
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Catherine M. K. Ho
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Vanessa Lucas
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Didier Ngabo
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Emma Rayner
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Kathryn A. Ryan
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Gillian S. Slack
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Stephen Thomas
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Nadina I. Wand
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Paul Yeates
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
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Christophe Demaison
2Ena Respiratory, Level 9, 31 Queen St, Melbourne, Victoria, 3000, Australia
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David C. Jackson
3Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria 3000, Australia
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Nathan W. Bartlett
4Viral Immunology and Respiratory Disease group and Priority Research Centre for Healthy Lungs, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
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Francesca Mercuri
2Ena Respiratory, Level 9, 31 Queen St, Melbourne, Victoria, 3000, Australia
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  • For correspondence: miles.carroll@phe.gov.uk fm@enarespiratory.com
Miles W. Carroll
1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
5Nuffield Dept of Medicine, Oxford University, Oxford, UK
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  • For correspondence: miles.carroll@phe.gov.uk fm@enarespiratory.com
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Article Information

doi 
https://doi.org/10.1101/2020.09.25.309914
History 
  • September 25, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Pamela C. Proud1,6,
  2. Daphne Tsitoura2,6,
  3. Robert J. Watson1,
  4. Brendon Y Chua3,
  5. Marilyn J. Aram1,
  6. Kevin R. Bewley1,
  7. Breeze E. Cavell1,
  8. Rebecca Cobb1,
  9. Stuart Dowall1,
  10. Susan A. Fotheringham1,
  11. Catherine M. K. Ho1,
  12. Vanessa Lucas1,
  13. Didier Ngabo1,
  14. Emma Rayner1,
  15. Kathryn A. Ryan1,
  16. Gillian S. Slack1,
  17. Stephen Thomas1,
  18. Nadina I. Wand1,
  19. Paul Yeates1,
  20. Christophe Demaison2,
  21. David C. Jackson3,
  22. Nathan W. Bartlett4,
  23. Francesca Mercuri2,7,# and
  24. Miles W. Carroll1,5,7,#
  1. 1National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG
  2. 2Ena Respiratory, Level 9, 31 Queen St, Melbourne, Victoria, 3000, Australia
  3. 3Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria 3000, Australia
  4. 4Viral Immunology and Respiratory Disease group and Priority Research Centre for Healthy Lungs, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
  5. 5Nuffield Dept of Medicine, Oxford University, Oxford, UK
  1. ↵#Correspondence to:
    Professor Miles W. Carroll, National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, United Kingdom SP4 0JG, Email: miles.carroll{at}phe.gov.uk, Telephone: 01980 612100, Dr Francesca Mercuri, Director of Operations, Ena Respiratory, Level 9, 31 Queen St, Melbourne, Victoria 3000, Australia, Email: fm{at}enarespiratory.com, Telephone: +61 411 403 241
  1. ↵6 These authors contributed equally

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Prophylactic intranasal administration of a TLR2 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model
Pamela C. Proud, Daphne Tsitoura, Robert J. Watson, Brendon Y Chua, Marilyn J. Aram, Kevin R. Bewley, Breeze E. Cavell, Rebecca Cobb, Stuart Dowall, Susan A. Fotheringham, Catherine M. K. Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A. Ryan, Gillian S. Slack, Stephen Thomas, Nadina I. Wand, Paul Yeates, Christophe Demaison, David C. Jackson, Nathan W. Bartlett, Francesca Mercuri, Miles W. Carroll
bioRxiv 2020.09.25.309914; doi: https://doi.org/10.1101/2020.09.25.309914
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Prophylactic intranasal administration of a TLR2 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model
Pamela C. Proud, Daphne Tsitoura, Robert J. Watson, Brendon Y Chua, Marilyn J. Aram, Kevin R. Bewley, Breeze E. Cavell, Rebecca Cobb, Stuart Dowall, Susan A. Fotheringham, Catherine M. K. Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A. Ryan, Gillian S. Slack, Stephen Thomas, Nadina I. Wand, Paul Yeates, Christophe Demaison, David C. Jackson, Nathan W. Bartlett, Francesca Mercuri, Miles W. Carroll
bioRxiv 2020.09.25.309914; doi: https://doi.org/10.1101/2020.09.25.309914

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