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Synthetic auxotrophy remains stable after continuous evolution and in co-culture with mammalian cells
View ORCID ProfileAditya M. Kunjapur, Michael G. Napolitano, Eriona Hysolli, Karen Noguera, Evan M. Appleton, Max G. Schubert, Michaela A. Jones, Siddharth Iyer, Daniel J. Mandell, George M. Church
doi: https://doi.org/10.1101/2020.09.27.315804
Aditya M. Kunjapur
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
2Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, CLB 215, Newark, DE 19716, USA
Michael G. Napolitano
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
3Ginkgo Bioworks, 27 Drydock Avenue, 8th Floor, Boston, MA 02210, USA
Eriona Hysolli
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
Karen Noguera
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
Evan M. Appleton
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
Max G. Schubert
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
Michaela A. Jones
2Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, CLB 215, Newark, DE 19716, USA
Siddharth Iyer
4Johns Hopkins University, 3101 Wyman Park Drive, Baltimore, MD 21218, USA
Daniel J. Mandell
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
5GRO Biosciences, 700 Main Street North, Cambridge, MA 02139, USA
George M. Church
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 238, Boston, MA 02115, USA
Posted September 28, 2020.
Synthetic auxotrophy remains stable after continuous evolution and in co-culture with mammalian cells
Aditya M. Kunjapur, Michael G. Napolitano, Eriona Hysolli, Karen Noguera, Evan M. Appleton, Max G. Schubert, Michaela A. Jones, Siddharth Iyer, Daniel J. Mandell, George M. Church
bioRxiv 2020.09.27.315804; doi: https://doi.org/10.1101/2020.09.27.315804
Synthetic auxotrophy remains stable after continuous evolution and in co-culture with mammalian cells
Aditya M. Kunjapur, Michael G. Napolitano, Eriona Hysolli, Karen Noguera, Evan M. Appleton, Max G. Schubert, Michaela A. Jones, Siddharth Iyer, Daniel J. Mandell, George M. Church
bioRxiv 2020.09.27.315804; doi: https://doi.org/10.1101/2020.09.27.315804
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