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Probabilistic mapping of human functional brain networks identifies regions of high group consensus

Ally Dworetsky, Benjamin A. Seitzman, Babatunde Adeyemo, Maital Neta, Rebecca S. Coalson, Steven E. Petersen, Caterina Gratton
doi: https://doi.org/10.1101/2020.09.28.313791
Ally Dworetsky
1Department of Radiology, Washington University School of Medicine
7Department of Psychology, Northwestern University
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Benjamin A. Seitzman
2Department of Neurology, Washington University School of Medicine
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Babatunde Adeyemo
2Department of Neurology, Washington University School of Medicine
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Maital Neta
6Department of Psychology, University of Nebraska-Lincoln
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Rebecca S. Coalson
1Department of Radiology, Washington University School of Medicine
2Department of Neurology, Washington University School of Medicine
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Steven E. Petersen
1Department of Radiology, Washington University School of Medicine
2Department of Neurology, Washington University School of Medicine
3Department of Psychological and Brain Sciences, Washington University School of Medicine
4Department of Neuroscience, Washington University School of Medicine
5Department of Biomedical Engineering, Washington University School of Medicine
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Caterina Gratton
7Department of Psychology, Northwestern University
8Department of Neurology, Northwestern University
9Interdepartmental Neuroscience Program, Northwestern University
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  • For correspondence: cgratton@northwestern.edu
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ABSTRACT

Many recent developments surrounding the functional network organization of the human brain have focused on data that have been averaged across groups of individuals. While such group-level approaches have shed considerable light on the brain’s large-scale distributed systems, they conceal individual differences in network organization, which recent work has demonstrated to be common and widespread. Here our goal was to leverage information about individual-level brain organization to identify locations of high inter-subject consensus. We probabilistically mapped 14 functional networks in multiple datasets with relatively high amounts of data. All networks show “core” (high-probability) regions, but differ from one another in the extent of their higher-variability components. These patterns replicate well across datasets with different scanning parameters. We produced a set of high-probability regions of interest (ROIs) from these probabilistic maps; these and the probabilistic maps are made publicly available, allowing researchers to apply information about group consistency to their own work in rest- or task-based studies.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 29, 2020.
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Probabilistic mapping of human functional brain networks identifies regions of high group consensus
Ally Dworetsky, Benjamin A. Seitzman, Babatunde Adeyemo, Maital Neta, Rebecca S. Coalson, Steven E. Petersen, Caterina Gratton
bioRxiv 2020.09.28.313791; doi: https://doi.org/10.1101/2020.09.28.313791
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Probabilistic mapping of human functional brain networks identifies regions of high group consensus
Ally Dworetsky, Benjamin A. Seitzman, Babatunde Adeyemo, Maital Neta, Rebecca S. Coalson, Steven E. Petersen, Caterina Gratton
bioRxiv 2020.09.28.313791; doi: https://doi.org/10.1101/2020.09.28.313791

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